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DB01147 : cloxacillin

Approved drug cloxacillin ... 6 targets DB01147

Generic name: cloxacillin PDB Het Group: CXN
 
Brand name(s): novo-cloxin, nu-cloxi.
Formula: C19H18Cln3O5S
IUPAC Formula: (2s,5r,6r)-6-[3-(2-Chlorophenyl)-5-Methyl-1,2-Oxazole-4-Amido]-3,3-Dimethyl-7-Oxo-4-Thia-1-
Azabicyclo[3.2.0]heptane-2-Carboxylic acid
PDB name: Cloxacillin

6
There are 6 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q8XJ01 (PBPA_CLOPE)  -  Penicillin-binding proteins 1A/1B
UniProt id: Q8XJ01    679 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P00811 (AMPC_ECOLI)  -  Beta-lactamase
UniProt id: P00811    376 a.a.  
1. 2hds A,B     358 a.a. 358   X-ray 1.16 Å
  2. 4kz5 A,B     358 a.a. 358   X-ray 1.35 Å
  3. 4kzb A,B     358 a.a. 358   X-ray 1.37 Å
  4. 4kz4 A,B     358 a.a. 358   X-ray 1.42 Å
  5. 4e3k A,B     358 a.a. 358   X-ray 1.43 Å
   more ...
There are no PDB entries containing cloxacillin bound to this target protein, although there are 92 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: Q8DNB6 (Q8DNB6_STRR6)  -  Penicillin-binding protein 2a
UniProt id: Q8DNB6    731 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P0A3M5 (PBP2_STRPN)  -  Penicillin-binding protein 2B
UniProt id: P0A3M5    680 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: Q51504 (Q51504_PSEAI)  -  Penicillin-binding protein 3
UniProt id: Q51504    578 a.a.  
1. 3ocn A     503 a.a. 503   X-ray 2.61 Å
  2. 4l0l A     501 a.a. 501   X-ray 2.10 Å
  3. 4fsf A     501 a.a. 501   X-ray 2.20 Å
  4. 3pbs A     499 a.a. 499   X-ray 2.00 Å
  5. 3ocl A     498 a.a. 498   X-ray 2.30 Å
   more ...
There are no PDB entries containing cloxacillin bound to this target protein, although there are 9 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 6:   UniProt id: P0AEB3 (DACA_ECOL6)  -  Penicillin-binding protein 5
UniProt id: P0AEB3    403 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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