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DB01143 : amifostine

Approved drug amifostine ... 2 targets DB01143

Generic name: amifostine
 
Brand name(s): ethyol.
Formula: C5H15N2O3Ps
IUPAC Formula: ({2-[(3-Aminopropyl)amino]ethyl}sulfanyl)phosphonic acid

2
There are 2 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P10696 (PPBN_HUMAN)  -  Alkaline phosphatase, placental-like
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P22413 (ENPP1_HUMAN)  -  Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
UniProt id: P22413    924 a.a.  
2ys0 A     56 a.a. 42   NMR  
There are no PDB entries containing amifostine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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