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DB01137 : levofloxacin

Approved drug levofloxacin ... 3 targets DB01137

Generic name: levofloxacin PDB Het Group: LFX
 
3 structures in PDB
Brand name(s): cravit, cravit ophthalmic, elequine, floxel, iquix, leroxacin, lesacin, levaquin, levokacin, levox, levoxacin, mosardal, nofaxin, quixin, reskuin, tavanic, volequin.
Formula: C18H20Fn3O4
IUPAC Formula: (2s)-7-Fluoro-2-Methyl-6-(4-Methylpiperazin-1-Yl)-10-Oxo-4-Oxa-1-Azatricyclo[7.3.1.0^{5,13}]trideca-
5(13),6,8,11-Tetraene-11-Carboxylic acid
PDB name: (3s)-9-Fluoro-3-Methyl-10-(4-Methylpiperazin-1-Yl)-7-Oxo-2,3-Dihydro-7h-[1,4]oxazino[2,3,4-
Ij]quinoline-6-Carboxylic acid

3
There are 3 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P43702 (PARC_HAEIN)  -  DNA topoisomerase 4 subunit A
UniProt id: P43702    747 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P43700 (GYRA_HAEIN)  -  DNA gyrase subunit A
UniProt id: P43700    880 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P11388 (TOP2A_HUMAN)  -  DNA topoisomerase 2-alpha
UniProt id: P11388    1530 a.a.  
1. 1lwz A     779 a.a. 771   Theor. model
  2. 4fm9 A     727 a.a. 727   X-ray 2.90 Å
  3. 1zxm A,B     373 a.a. 373   X-ray 1.87 Å
  4. 1zxn A,B,C,D     366 a.a. 366   X-ray 2.51 Å
There are no PDB entries containing levofloxacin bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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