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DB01132 : pioglitazone

Approved drug pioglitazone ... 1 target DB01132

Generic name: pioglitazone PDB Het Group: P1B
 
2 structures in PDB
Brand name(s): actos, actost, glustin.
Formula: C19H20N2O3S
IUPAC Formula: 5-({4-[2-(5-Ethylpyridin-2-Yl)ethoxy]phenyl}methyl)-1,3-Thiazolidine-2,4-Dione
PDB name: (5r)-5-{4-[2-(5-Ethylpyridin-2-Yl)ethoxy]benzyl}-1,3-Thiazolidine-2,4-Dione

1
There is 1 target protein defined in DrugBank for this drug.
 1 
The target protein has one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
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Target proteins

DrugBank drug Target 1:   UniProt id: P37231 (PPARG_HUMAN)  -  Peroxisome proliferator-activated receptor gamma
UniProt id: P37231    504 a.a.  
2xkw A,B   261 a.a. 261   X-ray 2.02 Å
The PDB contains 1 entry of pioglitazone bound to this target protein and 122 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

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