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DB01123 : proflavine

Approved drug proflavine ... 4 targets DB01123

Generic name: proflavine PDB Het Group: PRL
 
8 structures in PDB
Brand name(s): isoflav base, pro-gen, proflavin, profoliol-b, proformiphen, profura, progarmed, progesic.
Formula: C13H11N3
IUPAC Formula: Acridine-3,6-Diamine
PDB name: Proflavin

4
There are 4 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
 3 
There are 3 PDB structures of the drug molecule bound to its target protein.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   Bacterial outer membrane
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P00734 (THRB_HUMAN)  -  Prothrombin
UniProt id: P00734    621 a.a.  
1bcu L   26 a.a. 26   X-ray 2.00 Å
The PDB contains 2 entries of proflavine bound to this target protein and 353 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 3:   UniProt id: P0A0N4 (QACR_STAAU)  -  HTH-type transcriptional regulator qacR
UniProt id: P0A0N4    187 a.a.  
1. 1qvt B,D,A,E     186 a.a. 185   X-ray 2.89 Å
  2. 1jt0 A,B,C,D     188 a.a. 185   X-ray 2.90 Å
  3. 1qvu B,D,A,E     186 a.a. 185   X-ray 2.96 Å
  4. 1jt6 B,D,A,E     186 a.a. 184   X-ray 2.54 Å
  5. 1rkw B,D,A,E     186 a.a. 184   X-ray 2.62 Å
   more ...
There are no PDB entries containing proflavine bound to this target protein, although there are 14 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: Q58L87 (Q58L87_MYCSM)  -  TetR family transcriptional repressor LfrR
UniProt id: Q58L87    188 a.a.  
2v57 A,B,C,D   171 a.a. 171   X-ray 1.90 Å
The PDB contains 1 entry of proflavine bound to this target protein and 2 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with proflavine bound in the PDB

There is 1 "non-target" protein in the PDB containing the proflavine molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: Q79SH7 ()  -  EbrA repressor OS=Streptomyces lividans GN=ebrR PE=1 SV=1
UniProt id: Q79SH7    196 a.a.  
3hth A,B,C   171 a.a. 171   X-ray 2.70 Å
The PDB contains 1 entry of proflavine bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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