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DB01119 : diazoxide

Approved drug diazoxide ... 6 targets DB01119

Generic name: diazoxide PDB Het Group: 20J
 
1 structure in PDB
Brand name(s): dizoxide, eudemine, hyperstat, hypertonalum, mutabase, proglicem, proglycem.
Formula: C8H7Cln2O2S
IUPAC Formula: 7-Chloro-3-Methyl-4h-1l^{6},2,4-Benzothiadiazine-1,1-Dione
PDB name: 7-Chloro-3-Methyl-2h-1,2,4-Benzothiadiazine 1,1-Dioxide

6
There are 6 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q14654 (KCJ11_HUMAN)  -  ATP-sensitive inward rectifier potassium channel 11
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P00915 (CAH1_HUMAN)  -  Carbonic anhydrase 1
UniProt id: P00915    260 a.a.  
1. 1bzm A     260 a.a. 260   X-ray 2.00 Å
  2. 1czm A     260 a.a. 260   X-ray 2.00 Å
  3. 2nmx A,B     258 a.a. 258   X-ray 1.55 Å
  4. 1hcb A     258 a.a. 258   X-ray 1.60 Å
  5. 2nn1 A,B     258 a.a. 258   X-ray 1.65 Å
   more ...
There are no PDB entries containing diazoxide bound to this target protein, although there are 19 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P00918 (CAH2_HUMAN)  -  Carbonic anhydrase 2
UniProt id: P00918    259 a.a.  
1. 1lug A     259 a.a. 259   X-ray
  2. 2qo8 A     259 a.a. 259   X-ray 1.40 Å
  3. 4r5b A     260 a.a. 259   X-ray 1.50 Å
  4. 3igp A     259 a.a. 259   X-ray 1.65 Å
  5. 3sbh A     259 a.a. 259   X-ray 1.65 Å
   more ...
There are no PDB entries containing diazoxide bound to this target protein, although there are 500 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P05023 (AT1A1_HUMAN)  -  Sodium/potassium-transporting ATPase alpha-1 chain
UniProt id: P05023    1023 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: Q12791 (KCMA1_HUMAN)  -  Calcium-activated potassium channel subunit alpha 1
UniProt id: Q12791    1235 a.a.  
1. 3naf A     632 a.a. 616   X-ray 3.10 Å
  2. 3mt5 A     593 a.a. 593   X-ray 3.00 Å
  3. 2k44 A     28 a.a. 28   NMR  
There are no PDB entries containing diazoxide bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 6:   UniProt id: P55017 (S12A3_HUMAN)  -  Solute carrier family 12 member 3
UniProt id: P55017    1021 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

Other proteins with diazoxide bound in the PDB

There is 1 "non-target" protein in the PDB containing the diazoxide molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P43490 ()  -  Nicotinamide phosphoribosyltransferase OS=Homo sapiens GN=NAMPT PE=1 SV=1
UniProt id: P43490    490 a.a.  
4lv9 A,B   469 a.a. 469   X-ray 1.81 Å
The PDB contains 1 entry of diazoxide bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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