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DB01115 : nifedipine

Approved drug nifedipine ... 8 targets DB01115

Generic name: nifedipine
 
Brand name(s): adalat, adalat 10, adalat 20, adalat 5, adalat cc, adalat cr, adalat crono, adalat ft, adalat gits, adalat gits 30, adalat la, adalat lp, adalat oros, adalat pa, adalat retard, adalate, adapine, adapress, alat, aldipin, alfadal, alonix, alonix s, alpha-nifedipine retard, angipec, anifed, anpine, apo-nifed, aprical, bonacid, calcibloc, calcigard, calcilat, camont, cardifen, cardilat, cardionorm, chronadalate, chronadalate lp, citilat, coracten, coral, cordafen, cordaflex, cordalat, cordicant, cordilan, cordipin, corinfar, corotrend, corynphar, depin, dignokonstant, dilafed, dipinkor, duranifin, ecodipi, ecodipin, ecodipin e, fedcor, fedcor retard, fenamon, fenamon sr, fenihidin, fenihidine, glopir, hadipin, hexadilat, introcar, kordafen, macorel, megalat, myogard, n1fedilat, nedipin, nicardia, nifangin, nifar, nifdemin, nifebene, nifecard, nifecor, nifedepat, nifedicor, nifedin, nifedine, nifedipine retard, nifedipres, nifedirex lp, nifelan, nifelat, nifelat q, nifelate, nifensar xl, nificard, nifidine, nifipen, niphedipine, orix, oxcord, pidilat, procardia, procardia xl, sepamit, tibricol, zenusin.
Formula: C17H18N2O6
IUPAC Formula: 3,5-Dimethyl 2,6-Dimethyl-4-(2-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate

8
There are 8 target proteins defined in DrugBank for this drug.
 4 
4 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q13936 (CAC1C_HUMAN)  -  Voltage-dependent L-type calcium channel subunit alpha-1C
UniProt id: Q13936    2220 a.a.  
1. 3g43 E     68 a.a. 66   X-ray 2.10 Å
  2. 3oxq E,F     64 a.a. 63   X-ray 2.55 Å
  3. 2be6 D     29 a.a. 29   X-ray 2.00 Å
  4. 2lqc B     24 a.a. 22   NMR  
  5. 2f3z B     18 a.a. 16   X-ray 1.60 Å
There are no PDB entries containing nifedipine bound to this target protein, although there are 6 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P54289 (CA2D1_HUMAN)  -  Voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt id: P54289    1103 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: Q08289 (CACB2_HUMAN)  -  Voltage-dependent L-type calcium channel subunit beta-2
UniProt id: Q08289    660 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: Q01668 (CAC1D_HUMAN)  -  Voltage-dependent L-type calcium channel subunit alpha-1D
UniProt id: Q01668    2161 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: Q13698 (CAC1S_HUMAN)  -  Voltage-dependent L-type calcium channel subunit alpha-1S
UniProt id: Q13698    1872 a.a.  
2vay B     21 a.a. 21   X-ray 1.94 Å
There are no PDB entries containing nifedipine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 6:   UniProt id: P62158 (CALM_HUMAN)  -  Calmodulin
UniProt id: P62158    148 a.a.  
1. 4djc A     151 a.a. 148   X-ray 1.35 Å
  2. 2jzi A     148 a.a. 148   NMR  
  3. 2k0e A     148 a.a. 148   NMR  
  4. 2kne A     148 a.a. 148   NMR  
  5. 2l53 A     148 a.a. 148   NMR  
   more ...
There are no PDB entries containing nifedipine bound to this target protein, although there are 90 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 7:   UniProt id: Q09470 (KCNA1_HUMAN)  -  Potassium voltage-gated channel subfamily A member 1
UniProt id: Q09470    494 a.a.  
2afl A,B,C,D     82 a.a. 82   Theor. model
There are no PDB entries containing nifedipine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 8:   UniProt id: O95180 (CAC1H_HUMAN)  -  Voltage-dependent T-type calcium channel subunit alpha-1H
UniProt id: O95180    2353 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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