spacer
spacer

Search 

DB01108 : trilostane

Approved drug trilostane ... 4 targets DB01108

Generic name: trilostane
 
Brand name(s): desopan, modrastane, modrenal.
Formula: C20H27No3
IUPAC Formula: (1s,2r,6r,8s,11s,12s,15s,16s)-5,15-Dihydroxy-2,16-Dimethyl-7-
Oxapentacyclo[9.7.0.0^{2,8}.0^{6,8}.0^{12,16}]octadec-4-Ene-4-Carbonitrile

4
There are 4 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
Links  
DrugBank
ChEBI
KEGG drug
PubChem
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: P14060 (3BHS1_HUMAN)  -  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I
UniProt id: P14060    373 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P26439 (3BHS2_HUMAN)  -  3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II
UniProt id: P26439    372 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P03372 (ESR1_HUMAN)  -  Estrogen receptor
UniProt id: P03372    594 a.a.  
1. 1qku A,B,C     250 a.a. 250   X-ray 3.20 Å
  2. 3ert A     247 a.a. 247   X-ray 1.90 Å
  3. 1g50 A,B,C     247 a.a. 247   X-ray 2.90 Å
  4. 2ouz A     246 a.a. 246   X-ray 2.00 Å
  5. 3erd A,B     246 a.a. 246   X-ray 2.03 Å
   more ...
There are no PDB entries containing trilostane bound to this target protein, although there are 93 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: Q92731 (ESR2_HUMAN)  -  Estrogen receptor beta
UniProt id: Q92731    529 a.a.  
1. 3oll A,B     234 a.a. 233   X-ray 1.50 Å
  2. 1l2j A,B     232 a.a. 232   X-ray 2.95 Å
  3. 1u3r A,B     231 a.a. 231   X-ray 2.21 Å
  4. 1nde A     231 a.a. 231   X-ray 3.00 Å
  5. 1qkm A     230 a.a. 230   X-ray 1.80 Å
   more ...
There are no PDB entries containing trilostane bound to this target protein, although there are 30 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer
LIGPLOT diagrams
Press button below for LIGPLOT diagrams of drug-protein interactions in all selected structures above.

  spacer

spacer