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DB01103 : quinacrine

Approved drug quinacrine ... 4 targets DB01103

Generic name: quinacrine PDB Het Group: QUN
 
1 structure in PDB
Brand name(s): acrichine, acrinamine, acriquine, akrichin, antimalarina, atabrine, atebrin, atebrine, erion, erion hydrochloride, haffkinine, italchine, mepacrine, quinactine.
Formula: C23H30Cln3O
IUPAC Formula: {4-[(6-Chloro-2-Methoxyacridin-9-Yl)amino]pentyl}diethylamine
PDB name: Quinacrine

4
There are 4 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   Bacterial outer membrane
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: O60733 (PLPL9_HUMAN)  -  85 kDa calcium-independent phospholipase A2
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P47712 (PA24A_HUMAN)  -  Cytosolic phospholipase A2
UniProt id: P47712    748 a.a.  
1. 1cjy A,B     633 a.a. 632   X-ray 2.50 Å
  2. 1rlw A     126 a.a. 123   X-ray 2.40 Å
  3. 1bci A     123 a.a. 123   NMR  
There are no PDB entries containing quinacrine bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: Q15111 (PLCL1_HUMAN)  -  Phospholipase C
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

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