spacer
spacer

Search 

DB01088 : iloprost

Approved drug iloprost ... 7 targets DB01088

Generic name: iloprost
 
Brand name(s): ventavis.
Formula: C30H38O5
IUPAC Formula: 2-Oxo-2-Phenylethyl 5-[(2z)-5-Hydroxy-4-[(1e)-3-Hydroxy-4-Methyloct-1-En-6-Yn-1-Yl]-
Octahydropentalen-2-Ylidene]pentanoate

7
There are 7 target proteins defined in DrugBank for this drug.
 5 
5 of these target proteins have one or more structures in the PDB.
Links  
DrugBank
RxList
PubChem
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: P43119 (PI2R_HUMAN)  -  Prostacyclin receptor
UniProt id: P43119    386 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P34995 (PE2R1_HUMAN)  -  Prostaglandin E2 receptor, EP1 subtype
UniProt id: P34995    402 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P27815 (PDE4A_HUMAN)  -  CAMP-specific 3',5'-cyclic phosphodiesterase 4A
UniProt id: P27815    885 a.a.  
1. 2qyk A,B     334 a.a. 333   X-ray 2.10 Å
  2. 3tvx A,B     334 a.a. 333   X-ray 2.84 Å
  3. 3i8v A,B     334 a.a. 331   X-ray 2.25 Å
There are no PDB entries containing iloprost bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: Q07343 (PDE4B_HUMAN)  -  CAMP-specific 3',5'-cyclic phosphodiesterase 4B
UniProt id: Q07343    735 a.a.  
1. 4wzi A,B     412 a.a. 404   X-ray 2.58 Å
  2. 4x0f A,B     411 a.a. 403   X-ray 3.22 Å
  3. 3g45 A,B     371 a.a. 371   X-ray 2.63 Å
  4. 3hmv A,B     351 a.a. 350   X-ray 2.23 Å
  5. 1f0j A,B     351 a.a. 349   X-ray 1.77 Å
   more ...
There are no PDB entries containing iloprost bound to this target protein, although there are 39 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 5:   UniProt id: Q08493 (PDE4C_HUMAN)  -  CAMP-specific 3',5'-cyclic phosphodiesterase 4C
UniProt id: Q08493    711 a.a.  
1. 1lxu A     344 a.a. 344   Theor. model
  2. 2qym A     291 a.a. 291   X-ray 1.90 Å
There are no PDB entries containing iloprost bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 6:   UniProt id: Q08499 (PDE4D_HUMAN)  -  CAMP-specific 3',5'-cyclic phosphodiesterase 4D
UniProt id: Q08499    808 a.a.  
1. 3g58 A,B,C,D     335 a.a. 335   X-ray 2.05 Å
  2. 1oyn A,B,C,D     334 a.a. 334   X-ray 2.00 Å
  3. 2fm0 A,B,C,D     334 a.a. 334   X-ray 2.00 Å
  4. 2fm5 A,B,C,D     334 a.a. 334   X-ray 2.03 Å
  5. 1rko A,B,C,D     334 a.a. 334   X-ray 2.10 Å
   more ...
There are no PDB entries containing iloprost bound to this target protein, although there are 39 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 7:   UniProt id: P00750 (TPA_HUMAN)  - 
UniProt id: P00750    561 a.a.  
1. 1bda A,B     265 a.a. 265   X-ray 3.35 Å
  2. 1a5h A,B     252 a.a. 252   X-ray 2.90 Å
  3. 1rtf B     244 a.a. 244   X-ray 2.30 Å
  4. 1pk2 A     90 a.a. 90   NMR  
  5. 1tpg A     91 a.a. 90   NMR  
   more ...
There are no PDB entries containing iloprost bound to this target protein, although there are 9 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer
LIGPLOT diagrams
Press button below for LIGPLOT diagrams of drug-protein interactions in all selected structures above.

  spacer

spacer