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DB01082 : streptomycin

Approved drug streptomycin ... 2 targets DB01082

Generic name: streptomycin PDB Het Group: SRY
 
18 structures in PDB
Brand name(s): kantrex.
Formula: C21H39N7O12
IUPAC Formula: 1-[(1s,2r,3r,4s,5r,6r)-3-Carbamimidamido-6-{[(2r,3r,4r,5s)-3-{[(2s,3s,4s,5r,6s)-4,5-Dihydroxy-6-
(Hydroxymethyl)-3-(Methylamino)oxan-2-Yl]oxy}-4-Formyl-4-Hydroxy-5-Methyloxolan-2-Yl]oxy}-2,4,5-
Trihydroxycyclohexyl]guanidine
PDB name: Streptomycin

2
There are 2 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
 2 
There are 2 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P0A7S3 (RS12_ECOLI)  -  30S ribosomal protein S12
UniProt id: P0A7S3    123 a.a.  
1. 4kiy L     123 a.a. 123   X-ray 2.90 Å
  2. 4kj0 L     123 a.a. 123   X-ray 2.90 Å
  3. 4kj2 L     123 a.a. 123   X-ray 2.90 Å
  4. 4kj4 L     123 a.a. 123   X-ray 2.90 Å
  5. 4kj6 L     123 a.a. 123   X-ray 2.90 Å
   more ...
There are no PDB entries containing streptomycin bound to this target protein, although there are 93 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   Bacterial outer membrane
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

Other proteins with streptomycin bound in the PDB

There are 2 "non-target" proteins in the PDB containing the streptomycin molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: Q5HLN6 ()  -  Transcriptional regulator TcaR OS=Staphylococcus epidermidis (strain ATCC 35984 / RP62A) GN=tcaR PE=1 SV=1
UniProt id: Q5HLN6    150 a.a.  
4ejw A,B   136 a.a. 136   X-ray 2.80 Å
The PDB contains 1 entry of streptomycin bound to this protein
Protein 2:   UniProt id: Q9EVD7 ()  -  Aminoglycoside phosphotransferase OS=Enterococcus faecium GN=aph(2')-Ib PE=1 SV=1
UniProt id: Q9EVD7    298 a.a.  
3hav A,B,C   296 a.a. 295   X-ray 2.45 Å
The PDB contains 1 entry of streptomycin bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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