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DB01069 : promethazine

Approved drug promethazine ... 10 targets DB01069

Generic name: promethazine
 
Brand name(s): allergan, aprobit, avomine, dimapp, diphergan, diprazine, diprozin, dorme, duplamin, fargan, fellozine, fenazil, fenergan, fenetazina, genphen, hiberna, histargan, iergigan, isophenergan, lercigan, lergigan, mymethazine fortis, phargan, phenargan, phencen, phenergan, phenergan fortis, phensedyl, pilpophen, pipolphen, procit, prometasin, prometazin, prometh fortis, prometh plain, promethacon, promethaine, promethegan, prorex, protazine, provigan, pyrethia, pyrethiazine, remsed, romergan, tanidil, thiergan, valergine, vallergine, zipan-25.
Formula: C17H20N2S
IUPAC Formula: Dimethyl[1-(10h-Phenothiazin-10-Yl)propan-2-Yl]amine

10
There are 10 target proteins defined in DrugBank for this drug.
 5 
5 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P62158 (CALM_HUMAN)  -  Calmodulin
UniProt id: P62158    148 a.a.  
1. 4djc A     151 a.a. 148   X-ray 1.35 Å
  2. 2jzi A     148 a.a. 148   NMR  
  3. 2k0e A     148 a.a. 148   NMR  
  4. 2kne A     148 a.a. 148   NMR  
  5. 2l53 A     148 a.a. 148   NMR  
   more ...
There are no PDB entries containing promethazine bound to this target protein, although there are 90 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P35367 (HRH1_HUMAN)  -  Histamine H1 receptor
UniProt id: P35367    487 a.a.  
   more ...
There are no PDB entries containing promethazine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 3:   UniProt id: P14416 (DRD2_HUMAN)  -  D(2) dopamine receptor
UniProt id: P14416    442 a.a.  
1. 1i15 A     25 a.a. 25   Theor. model
  2. 2you B,C     14 a.a. 13   X-ray 2.19 Å
There are no PDB entries containing promethazine bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P11229 (ACM1_HUMAN)  -  Muscarinic acetylcholine receptor M1
UniProt id: P11229    460 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: P08172 (ACM2_HUMAN)  -  Muscarinic acetylcholine receptor M2
UniProt id: P08172    465 a.a.  
1. 4mqs A     277 a.a. 277   X-ray 3.50 Å
  2. 4mqt A     275 a.a. 275   X-ray 3.70 Å
  3. 1lub A     50 a.a. 49   Theor. model
There are no PDB entries containing promethazine bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 6:   UniProt id: P20309 (ACM3_HUMAN)  -  Muscarinic acetylcholine receptor M3
UniProt id: P20309    589 a.a.  
2csa A     19 a.a. 19   NMR  
There are no PDB entries containing promethazine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 7:   UniProt id: P08173 (ACM4_HUMAN)  -  Muscarinic acetylcholine receptor M4
UniProt id: P08173    479 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 8:   UniProt id: P08912 (ACM5_HUMAN)  -  Muscarinic acetylcholine receptor M5
UniProt id: P08912    532 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 9:   UniProt id: P35348 (ADA1A_HUMAN)  -  Alpha-1A adrenergic receptor
UniProt id: P35348    466 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 10:   UniProt id: P28223 (5HT2A_HUMAN)  -  5-hydroxytryptamine 2A receptor
UniProt id: P28223    471 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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