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DB01064 : isoproterenol

Approved drug isoproterenol ... 7 targets DB01064

Generic name: isoproterenol
 
Brand name(s): aerolone, aleudrin, aleudrine, aludrin, aludrine, asiprenol, asmalar, assiprenol, bellasthman, bronkephrine, euspiran, isadrine, isonorene, isonorin, isorenin, isuprel, isuprel mistometer, isupren, medihaler-iso, neo-epinine, neodrenal, norisodrine, norisodrine aerotrol, novodrin, proternol, respifral, saventrine, vapo-iso.
Formula: C11H17No3
IUPAC Formula: 4-{1-Hydroxy-2-[(Propan-2-Yl)amino]ethyl}benzene-1,2-Diol

7
There are 7 target proteins defined in DrugBank for this drug.
 6 
6 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P08588 (ADRB1_HUMAN)  -  Beta-1 adrenergic receptor
UniProt id: P08588    476 a.a.  
2lsq A     25 a.a. 19   NMR  
There are no PDB entries containing isoproterenol bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: P07550 (ADRB2_HUMAN)  -  Beta-2 adrenergic receptor
UniProt id: P07550    412 a.a.  
1. 3pds A     442 a.a. 292   X-ray 3.50 Å
  2. 4gbr A     286 a.a. 283   X-ray 3.99 Å
  3. 3kj6 A     222 a.a. 222   X-ray 3.40 Å
  4. 2r4r A     216 a.a. 216   X-ray 3.40 Å
  5. 2r4s A     216 a.a. 216   X-ray 3.40 Å
   more ...
There are no PDB entries containing isoproterenol bound to this target protein, although there are 16 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P13945 (ADRB3_HUMAN)  -  Beta-3 adrenergic receptor
UniProt id: P13945    407 a.a.  
2cdw A     408 a.a. 407   Theor. model
There are no PDB entries containing isoproterenol bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 4:   UniProt id: P28482 (MK01_HUMAN)  -  Mitogen-activated protein kinase 1
UniProt id: P28482    359 a.a.  
1. 3sa0 A     354 a.a. 351   X-ray 1.59 Å
  2. 2y9q A     350 a.a. 350   X-ray 1.55 Å
  3. 4fmq A     350 a.a. 350   X-ray 2.10 Å
  4. 1tvo A     350 a.a. 350   X-ray 2.50 Å
  5. 1wzy A     350 a.a. 350   X-ray 2.50 Å
   more ...
There are no PDB entries containing isoproterenol bound to this target protein, although there are 38 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 5:   UniProt id: P27986 (P85A_HUMAN)  -  Phosphatidylinositol 3-kinase regulatory subunit alpha
UniProt id: P27986    723 a.a.  
1. 4l23 B     277 a.a. 277   X-ray 2.50 Å
  2. 4l1b B     277 a.a. 277   X-ray 2.59 Å
  3. 4l2y B     277 a.a. 277   X-ray 2.80 Å
  4. 4ovu B     268 a.a. 268   X-ray 2.96 Å
  5. 4waf B     250 a.a. 250   X-ray 2.39 Å
   more ...
There are no PDB entries containing isoproterenol bound to this target protein, although there are 25 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 6:   UniProt id: O00459 (P85B_HUMAN)  -  Phosphatidylinositol 3-kinase regulatory subunit beta
UniProt id: O00459    727 a.a.  
1. 2xs6 A     166 a.a. 165   X-ray 2.09 Å
  2. 3mtt A     163 a.a. 163   X-ray 3.30 Å
  3. 3o5z A     82 a.a. 82   X-ray 2.01 Å
  4. 2kt1 A     82 a.a. 79   NMR  
There are no PDB entries containing isoproterenol bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 7:   UniProt id: Q92569 (P55G_HUMAN)  -  Phosphatidylinositol 3-kinase regulatory subunit gamma
UniProt id: Q92569    461 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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