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DB01059 : norfloxacin

Approved drug norfloxacin ... 3 targets DB01059

Generic name: norfloxacin
 
Brand name(s): chibroxin, noroxin.
Formula: C16H18Fn3O3
IUPAC Formula: 1-Ethyl-6-Fluoro-4-Oxo-7-(Piperazin-1-Yl)-1,4-Dihydroquinoline-3-Carboxylic acid

3
There are 3 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P43702 (PARC_HAEIN)  -  DNA topoisomerase 4 subunit A
UniProt id: P43702    747 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P43700 (GYRA_HAEIN)  -  DNA gyrase subunit A
UniProt id: P43700    880 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P11388 (TOP2A_HUMAN)  -  DNA topoisomerase 2-alpha
UniProt id: P11388    1530 a.a.  
1. 1lwz A     779 a.a. 771   Theor. model
  2. 4fm9 A     727 a.a. 727   X-ray 2.90 Å
  3. 1zxm A,B     373 a.a. 373   X-ray 1.87 Å
  4. 1zxn A,B,C,D     366 a.a. 366   X-ray 2.51 Å
There are no PDB entries containing norfloxacin bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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