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DB01054 : nitrendipine

Approved drug nitrendipine ... 8 targets DB01054

Generic name: nitrendipine
 
Brand name(s): bayotensin, baypress, bylotensin, deiten, nidrel, nitrepin.
Formula: C18H20N2O6
IUPAC Formula: 3-Ethyl 5-Methyl 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-Dicarboxylate

8
There are 8 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q13936 (CAC1C_HUMAN)  -  Voltage-dependent L-type calcium channel subunit alpha-1C
UniProt id: Q13936    2220 a.a.  
1. 3g43 E     68 a.a. 66   X-ray 2.10 Å
  2. 3oxq E,F     64 a.a. 63   X-ray 2.55 Å
  3. 2be6 D     29 a.a. 29   X-ray 2.00 Å
  4. 2lqc B     24 a.a. 22   NMR  
  5. 2f3z B     18 a.a. 16   X-ray 1.60 Å
There are no PDB entries containing nitrendipine bound to this target protein, although there are 6 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P54289 (CA2D1_HUMAN)  -  Voltage-dependent calcium channel subunit alpha-2/delta-1
UniProt id: P54289    1103 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: Q08289 (CACB2_HUMAN)  -  Voltage-dependent L-type calcium channel subunit beta-2
UniProt id: Q08289    660 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: Q06432 (CCG1_HUMAN)  -  Voltage-dependent calcium channel gamma-1 subunit
UniProt id: Q06432    222 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: Q01668 (CAC1D_HUMAN)  -  Voltage-dependent L-type calcium channel subunit alpha-1D
UniProt id: Q01668    2161 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: Q13698 (CAC1S_HUMAN)  -  Voltage-dependent L-type calcium channel subunit alpha-1S
  No Pfam domain assignments available for this protein.
2vay B     21 a.a. 21   X-ray 1.94 Å
There are no PDB entries containing nitrendipine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 7:   UniProt id: Q9NY47 (CA2D2_HUMAN)  -  Voltage-dependent calcium channel subunit alpha-2/delta-2
UniProt id: Q9NY47    1150 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 8:   UniProt id: O95180 (CAC1H_HUMAN)  -  Voltage-dependent T-type calcium channel subunit alpha-1H
UniProt id: O95180    2353 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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