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DB01047 : fluocinonide

Approved drug fluocinonide ... 2 targets DB01047

Generic name: fluocinonide
 
Brand name(s): bestasone, biscosal, cortalar, fluonex, fluzon, lidex, lidex e, lidex-e, lonide, lyderm, metosyn, straderm, synalar acetate, topsymin, topsyn, vanos.
Formula: C26H32F2O7
IUPAC Formula: 2-[(1s,2s,4r,8s,9s,11s,12r,13s,19s)-12,19-Difluoro-11-Hydroxy-6,6,9,13-Tetramethyl-16-Oxo-5,7-
Dioxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icosa-14,17-Dien-8-Yl]-2-Oxoethyl acetate

2
There are 2 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P04150 (GCR_HUMAN)  -  Glucocorticoid receptor
UniProt id: P04150    776 a.a.  
1. 1m2z A,D     255 a.a. 254   X-ray 2.50 Å
  2. 3bqd A     253 a.a. 252   X-ray 2.50 Å
  3. 3k22 A,B     250 a.a. 248   X-ray 2.10 Å
  4. 3e7c A,B     248 a.a. 246   X-ray 2.15 Å
  5. 4p6w A     252 a.a. 245   X-ray 1.95 Å
   more ...
There are no PDB entries containing fluocinonide bound to this target protein, although there are 15 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: Q99835 (SMO_HUMAN)  -  Smoothened homolog
UniProt id: Q99835    787 a.a.  
   more ...
There are no PDB entries containing fluocinonide bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

Structure selection

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