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DB01029 : irbesartan

Approved drug irbesartan ... 2 targets DB01029

Generic name: irbesartan
 
Brand name(s): avapro, irbesarran, irbesartan [usan:inn], lrbesartan.
Formula: C25H28N6O
IUPAC Formula: 2-Butyl-3-({4-[2-(2h-1,2,3,4-Tetrazol-5-Yl)phenyl]phenyl}methyl)-1,3-Diazaspiro[4.4]non-1-En-4-One

2
There are 2 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P30556 (AGTR1_HUMAN)  -  Type-1 angiotensin II receptor
UniProt id: P30556    358 a.a.  
1zv0 B     359 a.a. 358   Theor. model
There are no PDB entries containing irbesartan bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: P05412 (JUN_HUMAN)  -  Transcription factor AP-1
UniProt id: P05412    330 a.a.  
1. 1t2k C     62 a.a. 60   X-ray 3.00 Å
  2. 1fos F     57 a.a. 56   X-ray 3.05 Å
  3. 1jnm A,B     56 a.a. 55   X-ray 2.20 Å
  4. 1s9k E     52 a.a. 52   X-ray 3.10 Å
  5. 1a02 J     52 a.a. 51   X-ray 2.70 Å
There are no PDB entries containing irbesartan bound to this target protein, although there are 6 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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