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DB01026 : ketoconazole

Approved drug ketoconazole ... 1 target DB01026

Generic name: ketoconazole PDB Het Group: KTN
 
1 structure in PDB
Brand name(s): extina, fungarest, fungoral, ketoderm, ketoisdin, ketozole, nizoral, nizoral cream, nizoral shampoo, nizoral a-d, nizoral a-d shampoo, orifungal, orifungal m, panfungol, sebazole.
Formula: C26H28Cl2N4O4
IUPAC Formula: 1-[4-(4-{[2-(2,4-Dichlorophenyl)-2-(1h-Imidazol-1-Ylmethyl)-1,3-Dioxolan-4-
Yl]methoxy}phenyl)piperazin-1-Yl]ethan-1-One
PDB name: Cis-1-Acetyl-4-(4-((2-(2,4-Dichlorophenyl)-2-(1h-Imidazol-1-Ylmethyl)-1,3-Dioxolan-4-
Yl)methoxy)phenyl)piperazine

1
There is 1 target protein defined in DrugBank for this drug.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
Links  
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Information  
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Target proteins

DrugBank drug Target 1:   UniProt id: P10613 (CP51_CANAL)  -  Cytochrome P450 51
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:  

 

Other proteins with ketoconazole bound in the PDB

There is 1 "non-target" protein in the PDB containing the ketoconazole molecule bound. That is, the UniProt code for the protein is missing or does not match the drug target above.

Protein 1:   UniProt id: P08684 ()  -  Cytochrome P450 3A4 OS=Homo sapiens GN=CYP3A4 PE=1 SV=4
UniProt id: P08684    502 a.a.  
2j0c A,B,C,D   455 a.a. 455   X-ray 2.80 Å
The PDB contains 1 entry of ketoconazole bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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