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DB01025 : amlexanox

Approved drug amlexanox ... 4 targets DB01025

Generic name: amlexanox PDB Het Group: ANW
 
1 structure in PDB
Brand name(s): amlenanox, amoxanox, aphthasol, elics, oradisc, solfa.
Formula: C16H14N2O4
IUPAC Formula: 2-Amino-5-Oxo-7-(Propan-2-Yl)-5h-Chromeno[2,3-B]pyridine-3-Carboxylic acid
PDB name: 2-Amino-7-(1-Methylethyl)-5-Oxo-5h-Chromeno[2,3-B]pyridine-3-Carboxylic acid

4
There are 4 target proteins defined in DrugBank for this drug.
 4 
4 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
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Target proteins

DrugBank drug Target 1:   UniProt id: P80511 (S10AC_HUMAN)  -  Protein S100-A12
UniProt id: P80511    91 a.a.  
1. 2wcb A,B     92 a.a. 91   X-ray 1.73 Å
  2. 2m9g A,B     92 a.a. 91   NMR  
  3. 1odb A,B,C,D,...     91 a.a. 90   X-ray 2.19 Å
  4. 2wcf A,B,C,D,...     91 a.a. 90   X-ray 2.78 Å
  5. 2wce A,B     91 a.a. 89   X-ray 1.77 Å
   more ...
There are no PDB entries containing amlexanox bound to this target protein, although there are 8 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: Q99584 (S10AD_HUMAN)  -  Protein S100-A13
UniProt id: Q99584    97 a.a.  
2kot A,B   98 a.a. 97   NMR  
The PDB contains 1 entry of amlexanox bound to this target protein and 12 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 3:   UniProt id: P08700 (IL3_HUMAN)  -  Interleukin-3
UniProt id: P08700    151 a.a.  
1jli A     112 a.a. 98   NMR  
There are no PDB entries containing amlexanox bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 4:   UniProt id: P05230 (FGF1_HUMAN)  -  Fibroblast growth factor 1
UniProt id: P05230    154 a.a.  
1. 1ry7 A     151 a.a. 151   X-ray 3.20 Å
  2. 3ojm A     145 a.a. 145   X-ray 2.10 Å
  3. 3ba4 A,B     144 a.a. 138   X-ray 1.80 Å
  4. 1rg8 A,B     141 a.a. 137   X-ray 1.10 Å
  5. 1jqz A,B     141 a.a. 137   X-ray 1.65 Å
   more ...
There are no PDB entries containing amlexanox bound to this target protein, although there are 87 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

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