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DB01021 : trichlormethiazide

Approved drug trichlormethiazide ... 5 targets DB01021

Generic name: trichlormethiazide
 
Brand name(s): achletin, anatran, anistadin, aponorin, carvacron, chlopolidine, cretonin, diu-hydrin, diurazida, diurese, diuroral, esmarin, eurinol, fluitran, flurese, flutra, gangesol, hydrotrichlorothiazide, intromene, isestran, kubacron, metahydrin, metatensin, nakva, naqua, naquasone, salurin, schebitran, tachionin, tolcasone, trichlorex, trichlormas, trichlormetazid, trichlormethiazid, trichlormethiazide w/ reserpine, trichloromethiadiazide, trichloromethiazide, triclordiuride, triclormetiazide, triflumen.
Formula: C8H8Cl3N3O4S2
IUPAC Formula: 6-Chloro-3-(Dichloromethyl)-1,1-Dioxo-3,4-Dihydro-2h-1l^{6},2,4-Benzothiadiazine-7-Sulfonamide

5
There are 5 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q13621 (S12A1_HUMAN)  -  Solute carrier family 12 member 1
UniProt id: Q13621    1099 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P05023 (AT1A1_HUMAN)  -  Sodium/potassium-transporting ATPase alpha-1 chain
UniProt id: P05023    1023 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P00915 (CAH1_HUMAN)  -  Carbonic anhydrase 1
UniProt id: P00915    260 a.a.  
1. 1bzm A     260 a.a. 260   X-ray 2.00 Å
  2. 1czm A     260 a.a. 260   X-ray 2.00 Å
  3. 2nmx A,B     258 a.a. 258   X-ray 1.55 Å
  4. 1hcb A     258 a.a. 258   X-ray 1.60 Å
  5. 2nn1 A,B     258 a.a. 258   X-ray 1.65 Å
   more ...
There are no PDB entries containing trichlormethiazide bound to this target protein, although there are 19 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P00918 (CAH2_HUMAN)  -  Carbonic anhydrase 2
UniProt id: P00918    259 a.a.  
1. 1lug A     259 a.a. 259   X-ray
  2. 2qo8 A     259 a.a. 259   X-ray 1.40 Å
  3. 3igp A     259 a.a. 259   X-ray 1.65 Å
  4. 3sbh A     259 a.a. 259   X-ray 1.65 Å
  5. 1can A     259 a.a. 259   X-ray 1.90 Å
   more ...
There are no PDB entries containing trichlormethiazide bound to this target protein, although there are 479 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 5:   UniProt id: P22748 (CAH4_HUMAN)  -  Carbonic anhydrase 4
UniProt id: P22748    311 a.a.  
1. 1znc A     262 a.a. 262   X-ray 2.80 Å
  2. 3f7b A,B     257 a.a. 257   X-ray 2.05 Å
  3. 3fw3 A,B     249 a.a. 249   X-ray 1.72 Å
  4. 3f7u A,B,C,D     247 a.a. 247   X-ray 2.00 Å
There are no PDB entries containing trichlormethiazide bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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