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DB01016 : glyburide

Approved drug glyburide ... 8 targets DB01016

Generic name: glyburide
 
Brand name(s): abbenclamide, adiab, azuglucon, bastiverit, benclamin, betanase, betanese 5, calabren, cytagon, daonil, debtan, dia-basan, diabeta, diabiphage, dibelet, duraglucon, euclamin, euglucan, euglucon, euglucon 5, euglykon, gbn 5, gen-glybe, gewaglucon, gilemal, glamide, glibadone, gliban, gliben, gliben-puren n, glibenbeta, glibenclamid al, glibenclamid basics, glibenclamid fabra, glibenclamid genericon, glibenclamid heumann, glibenclamid riker m., glibenclamid-cophar, glibenclamid-ratiopharm, glibenil, glibens, glibesyn, glibet, glibetic, glibil, gliboral, glicem, glidiabet, glimel, glimide, glimidstata, glisulin, glitisol, glubate, gluben, gluco-tablimen, glucobene, glucohexal, glucolon, glucomid, glucoremed, glucoven, glyben, glybenclamide, glybenzcyclamide, glycolande, glycomin, glynase, hexaglucon, humedia, lederglib, libanil, lisaglucon, malix, maninil, med-glionil, melix, micronase, miglucan, nadib, neogluconin, norglicem 5, normoglucon, novo-glyburide, orabetic, pira, praeciglucon, prestab, prodiabet, renabetic, semi-daonil, sugril, suraben, tiabet, yuglucon.
Formula: C23H28Cln3O5S
IUPAC Formula: 5-Chloro-N-[2-(4-{[(Cyclohexylcarbamoyl)amino]sulfonyl}phenyl)ethyl]-2-Methoxybenzamide

8
There are 8 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q09428 (ABCC8_HUMAN)  -  ATP-binding cassette transporter sub-family C member 8
UniProt id: Q09428    1581 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P48048 (KCNJ1_HUMAN)  -  ATP-sensitive inward rectifier potassium channel 1
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P48544 (KCNJ5_HUMAN)  -  G protein-activated inward rectifier potassium channel 4
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: O60706 (ABCC9_HUMAN)  -  ATP-binding cassette transporter sub-family C member 9
UniProt id: O60706    1549 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: O95342 (ABCBB_HUMAN)  -  Bile salt export pump
UniProt id: O95342    1321 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: O95477 (ABCA1_HUMAN)  -  ATP-binding cassette sub-family A member 1
UniProt id: O95477    2261 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 7:   UniProt id: P13569 (CFTR_HUMAN)  -  Cystic fibrosis transmembrane conductance regulator
UniProt id: P13569    1479 a.a.  
1. 1xmi A,B,C,D,E     267 a.a. 262   X-ray 2.25 Å
  2. 2bbs A     253 a.a. 249   X-ray 2.05 Å
  3. 2bbo A     254 a.a. 249   X-ray 2.55 Å
  4. 2bbt A     249 a.a. 246   X-ray 2.30 Å
  5. 1xmj A     246 a.a. 229   X-ray 2.30 Å
   more ...
There are no PDB entries containing glyburide bound to this target protein, although there are 10 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 8:   UniProt id: Q14654 (KCJ11_HUMAN)  -  ATP-sensitive inward rectifier potassium channel 11
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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