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DB01015 : sulfamethoxazole

Approved drug sulfamethoxazole ... 2 targets DB01015

Generic name: sulfamethoxazole PDB Het Group: 08D
 
1 structure in PDB
Brand name(s): apo-sulfamethoxazole, azo-gantanol, bactrimel, gamazole, gantanol, gantanol-ds, metoxal, radonil, septran, simsinomin, sinomin, sulfamethalazole, sulfamethoxazol, sulfamethoxizole, sulfamethylisoxazole, sulfisomezole, sulpha-methoxizole, sulphamethalazole, sulphamethoxazol, sulphamethoxazole, sulphamethoxazole bp 98, sulphamethylisoxazole, sulphisomezole, trib, urobak.
Formula: C10H11N3O3S
IUPAC Formula: 4-Amino-N-(5-Methyl-1,2-Oxazol-3-Yl)benzene-1-Sulfonamide
PDB name: Sulfamethoxazole

2
There are 2 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P0AC13 (DHPS_ECOLI)  -  Dihydropteroate synthase
UniProt id: P0AC13    281 a.a.  
1. 1aj0 A     282 a.a. 281   X-ray 2.00 Å
  2. 1aj2 A     282 a.a. 281   X-ray 2.00 Å
  3. 1ajz A     282 a.a. 281   X-ray 2.00 Å
There are no PDB entries containing sulfamethoxazole bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P08192 (FOLC_ECOLI)  -  FolC bifunctional protein [Includes: Folylpolyglutamate synthase
UniProt id: P08192    421 a.a.  
1. 1w78 A     413 a.a. 412   X-ray 1.82 Å
  2. 1w7k A     410 a.a. 409   X-ray 2.10 Å
There are no PDB entries containing sulfamethoxazole bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

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