spacer
spacer

Search 

DB01004 : ganciclovir

Approved drug ganciclovir ... 3 targets DB01004

Generic name: ganciclovir PDB Het Group: GA2
 
2 structures in PDB
Brand name(s): cytovene, cytovene iv, cytovene-iv, vitrasert.
Formula: C9H13N5O4
IUPAC Formula: 2-Amino-9-{[(1,3-Dihydroxypropan-2-Yl)oxy]methyl}-6,9-Dihydro-3h-Purin-6-One
PDB name: 9-(1,3-Dihydroxy-Propoxymethane)guanine

3
There are 3 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
Links  
DrugBank
RxList
ChEBI
KEGG drug
PubChem
MSDChem
Ligand Expo
HIC-Up
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: P04293 (DPOL_HHV11)  -  DNA polymerase
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   Bacterial outer membrane
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P03176 (KITH_HHV11)  -  Thymidine kinase
UniProt id: P03176    375 a.a.  
1ki2 A,B   308 a.a. 308   X-ray 2.20 Å
The PDB contains 1 entry of ganciclovir bound to this target protein and 31 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with ganciclovir bound in the PDB

There is 1 "non-target" protein in the PDB containing the ganciclovir molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: O34925 ()  -  Purine nucleoside phosphorylase DeoD-type OS=Bacillus subtilis (strain 168) GN=deoD PE=1 SV=1
UniProt id: O34925    232 a.a.  
4da6 A   231 a.a. 230   X-ray 1.70 Å
The PDB contains 1 entry of ganciclovir bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer
LIGPLOT diagrams
Press button below for LIGPLOT diagrams of drug-protein interactions in all selected structures above.

  spacer

spacer