spacer
spacer

Search 

DB00990 : exemestane

Approved drug exemestane ... 1 target DB00990

Generic name: exemestane PDB Het Group: EXM
 
1 structure in PDB
Brand name(s): aromasin, exemestance.
Formula: C20H24O2
IUPAC Formula: (1s,2r,10r,11s,15s)-2,15-Dimethyl-8-Methylidenetetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-
Diene-5,14-Dione
PDB name: (8alpha,10alpha,13alpha)-6-Methylideneandrosta-1,4-Diene-3,17-Dione

1
There is 1 target protein defined in DrugBank for this drug.
 1 
The target protein has one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
Links  
DrugBank
RxList
ChEBI
KEGG drug
PubChem
MSDChem
Ligand Expo
HIC-Up
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: P11511 (CP19A_HUMAN)  -  Cytochrome P450 19A1
UniProt id: P11511    502 a.a.  
3s7s A   452 a.a. 452   X-ray 3.21 Å
The PDB contains 1 entry of exemestane bound to this target protein and 7 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer
LIGPLOT diagrams
Press button below for LIGPLOT diagrams of drug-protein interactions in all selected structures above.

  spacer

spacer