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DB00977 : ethinyl estradiol

Approved drug ethinyl estradiol ... 2 targets DB00977

Generic name: ethinyl estradiol
 
Brand name(s): estinyl.
Formula: C20H24O2
IUPAC Formula: (1s,10r,11s,14r,15s)-14-Ethynyl-15-Methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-
Triene-5,14-Diol

2
There are 2 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P03372 (ESR1_HUMAN)  -  Estrogen receptor
UniProt id: P03372    594 a.a.  
1. 1qku A,B,C     250 a.a. 250   X-ray 3.20 Å
  2. 3ert A     247 a.a. 247   X-ray 1.90 Å
  3. 1g50 A,B,C     247 a.a. 247   X-ray 2.90 Å
  4. 2ouz A     246 a.a. 246   X-ray 2.00 Å
  5. 3erd A,B     246 a.a. 246   X-ray 2.03 Å
   more ...
There are no PDB entries containing ethinyl estradiol bound to this target protein, although there are 102 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: O75469 (NR1I2_HUMAN)  -  Nuclear receptor subfamily 1 group I member 2
UniProt id: O75469    433 a.a.  
1. 1nrl A,B     278 a.a. 278   X-ray 2.00 Å
  2. 2o9i A,B     279 a.a. 278   X-ray 2.80 Å
  3. 4j5w A,B     294 a.a. 276   X-ray 2.80 Å
  4. 1m13 A     273 a.a. 273   X-ray 2.15 Å
  5. 3ctc A,B     287 a.a. 272   X-ray 2.10 Å
   more ...
There are no PDB entries containing ethinyl estradiol bound to this target protein, although there are 11 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

Structure selection

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