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DB00951 : isoniazid

Approved drug isoniazid ... 2 targets DB00951

Generic name: isoniazid PDB Het Group: ISZ
 
8 structures in PDB
Brand name(s): andrazide, antimicina, antituberkulosum, armacide, armazid, armazide, atcotibine, azuren, bacillin, cedin, cemidon, chemiazid, chemidon, cortinazine, cotinazin, cotinizin, defonin, dibutin, diforin, dinacrin, ditubin, ebidene, eralon, ertuban, eutizon, evalon, fsr 3, fimalene, gink, hidranizil, hidrasonil, hidrulta, hidrun, hycozid, hyozid, hyzyd, ido-tebin, idrazil, inah, inizid, iscotin, isidrina, ismazide, isobicina, isocid, isocidene, isocotin, isolyn, isonerit, isonex, isoniacid, isoniazid sa, isoniazide, isonicazide, isonicid, isonico, isonicotan, isonicotil, isonide, isonidrin, isonikazid, isonilex, isonin, isonindon, isonirit, isoniton, isonizide, isotamine, isotebe, isotebezid, isotinyl, isozide, isozyd, laniazid, laniozid, mybasan, neo-tizide, neoteben, neoxin, neumandin, nevin, niadrin, nicazide, nicetal, nicizina, niconyl, nicotibina, nicotibine, nicotisan, nicozide, nidaton, nidrazid, nikozid, niplen, nitadon, nydrazid, nyscozid, pelazid, percin, phthisen, pycazide, pyreazid, pyricidin, pyridicin, pyrizidin, raumanon, razide, retozide, rifamate, rimicid, rimifon, rimiphone, rimitsid, robiselin, robisellin, roxifen, sanohidrazina, sauterazid, sauterzid, stanozide, tb-phlogin, tb-razide, tb-vis, tebecid, tebenic, tebexin, tebilon, tebos, teebaconin, tekazin, tibazide, tibemid, tibison, tibivis, tibusan, tubazid, tubazide, tubeco, tubecotubercid, tuberian, tubicon, tubilysin, tubomel, tyvid, unicocyde, unicozyde, vazadrine, vederon, zidafimia, zinadon, zonazide.
Formula: C6H7N3O
IUPAC Formula: Pyridine-4-Carbohydrazide
PDB name: 4-(Diazenylcarbonyl)pyridine

2
There are 2 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
 8 
There are 8 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q08129 (KATG_MYCTO)  -  Peroxidase/catalase T
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P0A5Y6 (INHA_MYCTO)  -  Enoyl-[acyl-carrier-protein] reductase [NADH]
  No Pfam domain assignments available for this protein.
1. 2h7i A     268 a.a. 268   X-ray 1.62 Å
  2. 2h7m A     268 a.a. 268   X-ray 1.62 Å
  3. 2h7l A     268 a.a. 268   X-ray 1.73 Å
  4. 2h7p A     268 a.a. 268   X-ray 1.86 Å
  5. 2h7n A     268 a.a. 268   X-ray 1.90 Å
There are no PDB entries containing isoniazid bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).

Key:    Secondary structure  Bound drug molecule

 

Other proteins with isoniazid bound in the PDB

There are 6 "non-target" proteins in the PDB containing the isoniazid molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: O86309 ()  -  Arylamine N-acetyltransferase OS=Mycobacterium smegmatis GN=nat PE=1 SV=3
UniProt id: O86309    274 a.a.  
1w6f A,B,C,D   273 a.a. 273   X-ray 2.10 Å
The PDB contains 1 entry of isoniazid bound to this protein
Protein 2:   UniProt id: P00431 ()  -  Cytochrome c peroxidase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CCP1 PE=1 SV=2
UniProt id: P00431    360 a.a.  
2v2e A   291 a.a. 288   X-ray 1.68 Å
The PDB contains 1 entry of isoniazid bound to this protein
Protein 3:   UniProt id: P16544 ()  -  Putative ketoacyl reductase OS=Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) GN=actIII PE=1 SV=1
UniProt id: P16544    260 a.a.  
1xr3 A,B   256 a.a. 256   X-ray 2.71 Å
The PDB contains 1 entry of isoniazid bound to this protein
Protein 4:   UniProt id: P24627 ()  -  Lactotransferrin OS=Bos taurus GN=LTF PE=1 SV=2
UniProt id: P24627    707 a.a.  
3u72 A   335 a.a. 333   X-ray 2.20 Å
The PDB contains 1 entry of isoniazid bound to this protein
Protein 5:   UniProt id: P80025 ()  -  Lactoperoxidase OS=Bos taurus GN=LPO PE=1 SV=1
UniProt id: P80025    711 a.a.  
3i6n A   594 a.a. 593   X-ray 2.70 Å
The PDB contains 1 entry of isoniazid bound to this protein
Protein 6:   UniProt id: Q43758 ()  -  Ascorbate peroxidase OS=Glycine max GN=apx1 PE=1 SV=1
UniProt id: Q43758    249 a.a.  
1. 2vcf X   251 a.a. 249   X-ray 1.80 Å
  2. 2vcn A   249 a.a. 248   X-ray 1.20 Å
  3. 2vcs A   249 a.a. 248   X-ray 1.68 Å
The PDB contains 3 entries of isoniazid bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

Where there is more than one PDB model for a given UniProt sequence, the models are ordered by: 1. decreasing order of similarity to the UniProt sequence, 2. X-ray structures (in order of increasing resolution), NMR structures, and theoretical models. Clicking on any PDB code take you to the corresponding PDBsum page.

 

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