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DB00947 : fulvestrant

Approved drug fulvestrant ... 1 target DB00947

Generic name: fulvestrant PDB Het Group: FVS
 
1 structure in PDB
Brand name(s): faslodex.
Formula: C32H47F5O3S
IUPAC Formula: (1s,9r,11s,14s,15s)-15-Methyl-9-{9-[(4,4,5,5,5-
Pentafluoropentane)sulfinyl]nonyl}tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-Triene-5,14-
Diol
PDB name: (7beta,9beta,13alpha,17beta)-7-{9-[(R)-(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl}estra-1(10),2,4-
Triene-3,17-Diol

1
There is 1 target protein defined in DrugBank for this drug.
 1 
The target protein has one or more structures in the PDB.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
Links  
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Information  
Pharmacology
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Target proteins

DrugBank drug Target 1:   UniProt id: P03372 (ESR1_HUMAN)  -  Estrogen receptor
UniProt id: P03372    594 a.a.  
1. 1qku A,B,C     250 a.a. 250   X-ray 3.20 Å
  2. 3ert A     247 a.a. 247   X-ray 1.90 Å
  3. 1g50 A,B,C     247 a.a. 247   X-ray 2.90 Å
  4. 2ouz A     246 a.a. 246   X-ray 2.00 Å
  5. 3erd A,B     246 a.a. 246   X-ray 2.03 Å
   more ...
There are no PDB entries containing fulvestrant bound to this target protein, although there are 108 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

Other proteins with fulvestrant bound in the PDB

There is 1 "non-target" protein in the PDB containing the fulvestrant molecule bound. That is, the UniProt code for the protein is missing or does not match the drug target above.

Protein 1:   UniProt id: P34913 ()  -  Bifunctional epoxide hydrolase 2 OS=Homo sapiens GN=EPHX2 PE=1 SV=2
UniProt id: P34913    554 a.a.  
4j03 A   548 a.a. 547   X-ray 2.92 Å
The PDB contains 1 entry of fulvestrant bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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