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DB00928 : azacitidine

Approved drug azacitidine ... 3 targets DB00928

Generic name: azacitidine PDB Het Group: 5AE
 
1 structure in PDB
Brand name(s): ladakamycin, mylosar, vidaza.
Formula: C8H12N4O5
IUPAC Formula: 4-Amino-1-[(2r,3r,4s,5r)-3,4-Dihydroxy-5-(Hydroxymethyl)oxolan-2-Yl]-1,2-Dihydro-1,3,5-Triazin-2-One
PDB name: 4-Amino-1-(Beta-D-Ribofuranosyl)-1,3,5-Triazin-2(1h)-One

3
There are 3 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Information  
Pharmacology
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Target proteins

DrugBank drug Target 1:   UniProt id: P26358 (DNMT1_HUMAN)  -  DNA (cytosine-5)-methyltransferase 1
UniProt id: P26358    1615 a.a.  
1. 3swr A     965 a.a. 965   X-ray 2.49 Å
  2. 3pta A     904 a.a. 904   X-ray 3.60 Å
  3. 3epz A,B     227 a.a. 226   X-ray 2.31 Å
There are no PDB entries containing azacitidine bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   Bacterial outer membrane
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   Bacterial outer membrane
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

Other proteins with azacitidine bound in the PDB

There is 1 "non-target" protein in the PDB containing the azacitidine molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: Q9HVC3 ()  -  Peptidyl-tRNA hydrolase OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) GN=pth PE=1 SV=1
UniProt id: Q9HVC3    193 a.a.  
4qd3 A   194 a.a. 193   X-ray 1.89 Å
The PDB contains 1 entry of azacitidine bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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