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DB00920 : ketotifen

Approved drug ketotifen ... 10 targets DB00920

Generic name: ketotifen
 
Brand name(s): ketotifen, zaditor.
Formula: C19H19Nos
IUPAC Formula: 2-(1-Methylpiperidin-4-Ylidene)-6-Thiatricyclo[8.4.0.0^{3,7}]tetradeca-1(10),3(7),4,11,13-Pentaen-8-
One

10
There are 10 target proteins defined in DrugBank for this drug.
 9 
9 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P52209 (6PGD_HUMAN)  -  6-phosphogluconate dehydrogenase, decarboxylating
UniProt id: P52209    482 a.a.  
1. 2jkv A,B,C,D,...     482 a.a. 482   X-ray 2.53 Å
  2. 4gwg A     467 a.a. 467   X-ray 1.39 Å
  3. 4gwk A     467 a.a. 467   X-ray 1.53 Å
There are no PDB entries containing ketotifen bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P35367 (HRH1_HUMAN)  -  Histamine H1 receptor
UniProt id: P35367    487 a.a.  
   more ...
There are no PDB entries containing ketotifen bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 3:   UniProt id: P27815 (PDE4A_HUMAN)  -  CAMP-specific 3',5'-cyclic phosphodiesterase 4A
UniProt id: P27815    885 a.a.  
1. 2qyk A,B     334 a.a. 333   X-ray 2.10 Å
  2. 3tvx A,B     334 a.a. 333   X-ray 2.84 Å
  3. 3i8v A,B     334 a.a. 331   X-ray 2.25 Å
There are no PDB entries containing ketotifen bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: Q07343 (PDE4B_HUMAN)  -  CAMP-specific 3',5'-cyclic phosphodiesterase 4B
UniProt id: Q07343    735 a.a.  
1. 3g45 A,B     371 a.a. 371   X-ray 2.63 Å
  2. 3hmv A,B     351 a.a. 350   X-ray 2.23 Å
  3. 1f0j A,B     351 a.a. 349   X-ray 1.77 Å
  4. 1jp1 A     351 a.a. 349   Theor. model
  5. 1jp2 A     351 a.a. 349   Theor. model
   more ...
There are no PDB entries containing ketotifen bound to this target protein, although there are 36 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 5:   UniProt id: Q08499 (PDE4D_HUMAN)  -  CAMP-specific 3',5'-cyclic phosphodiesterase 4D
UniProt id: Q08499    808 a.a.  
1. 3g58 A,B,C,D     335 a.a. 335   X-ray 2.05 Å
  2. 1oyn A,B,C,D     334 a.a. 334   X-ray 2.00 Å
  3. 2fm0 A,B,C,D     334 a.a. 334   X-ray 2.00 Å
  4. 2fm5 A,B,C,D     334 a.a. 334   X-ray 2.03 Å
  5. 1rko A,B,C,D     334 a.a. 334   X-ray 2.10 Å
   more ...
There are no PDB entries containing ketotifen bound to this target protein, although there are 36 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 6:   UniProt id: Q08493 (PDE4C_HUMAN)  -  CAMP-specific 3',5'-cyclic phosphodiesterase 4C
UniProt id: Q08493    711 a.a.  
1. 1lxu A     344 a.a. 344   Theor. model
  2. 2qym A     291 a.a. 291   X-ray 1.90 Å
There are no PDB entries containing ketotifen bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 7:   UniProt id: Q13946 (PDE7A_HUMAN)  -  High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
UniProt id: Q13946    481 a.a.  
1. 3g3n A     318 a.a. 318   X-ray 2.40 Å
  2. 1zkl A     317 a.a. 317   X-ray 1.67 Å
There are no PDB entries containing ketotifen bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 8:   UniProt id: Q9NP56 (PDE7B_HUMAN)  -  CAMP-specific 3',5'-cyclic phosphodiesterase 7B
UniProt id: Q9NP56    449 a.a.  
1lxw A     330 a.a. 330   Theor. model
There are no PDB entries containing ketotifen bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 9:   UniProt id: O60658 (PDE8A_HUMAN)  -  High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
UniProt id: O60658    828 a.a.  
1. 1lhq A     340 a.a. 340   Theor. model
  2. 3ecm A     338 a.a. 338   X-ray 1.90 Å
  3. 3ecn A,B     338 a.a. 338   X-ray 2.10 Å
  4. 1lxx A     334 a.a. 334   Theor. model
There are no PDB entries containing ketotifen bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 10:   UniProt id: O95263 (PDE8B_HUMAN)  -  High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
UniProt id: O95263    885 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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