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DB00917 : dinoprostone

Approved drug dinoprostone ... 4 targets DB00917

Generic name: dinoprostone PDB Het Group: P2E
 
1 structure in PDB
Brand name(s): cervidil, prepidil, propess, prostarmon e, prostin e, prostin e2.
Formula: C20H32O5
IUPAC Formula: (5z)-7-[(1r,2r,3r)-3-Hydroxy-2-[(1e,3s)-3-Hydroxyoct-1-En-1-Yl]-5-Oxocyclopentyl]hept-5-Enoic acid
PDB name: (Z)-7-[(1r,2r,3r)-3-Hydroxy-2-[(E,3s)-3-Hydroxyoct-1-Enyl]-5-Oxo-Cyclopentyl]hept-5-Enoic acid

4
There are 4 target proteins defined in DrugBank for this drug.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P43116 (PE2R2_HUMAN)  -  Prostaglandin E2 receptor, EP2 subtype
UniProt id: P43116    358 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P34995 (PE2R1_HUMAN)  -  Prostaglandin E2 receptor, EP1 subtype
UniProt id: P34995    402 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P43115 (PE2R3_HUMAN)  -  Prostaglandin E2 receptor, EP3 subtype
UniProt id: P43115    390 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P35408 (PE2R4_HUMAN)  -  Prostaglandin E2 receptor EP4 subtype
UniProt id: P35408    488 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain

 

Other proteins with dinoprostone bound in the PDB

There is 1 "non-target" protein in the PDB containing the dinoprostone molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   Crystal structure of anti-prostaglandin e2 fab fragment pge2
  No Pfam domain assignments available for this protein.
1. 3wfh A   211 a.a. 211   X-ray 1.90 Å
  2.    " B   216 a.a. 50   "

Key:    Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

Where there is more than one PDB model for a given UniProt sequence, the models are ordered by: 1. decreasing order of similarity to the UniProt sequence, 2. X-ray structures (in order of increasing resolution), NMR structures, and theoretical models. Clicking on any PDB code take you to the corresponding PDBsum page.

 

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