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DB00909 : zonisamide

Approved drug zonisamide ... 31 targets DB00909

Generic name: zonisamide PDB Het Group: ZON
 
1 structure in PDB
Brand name(s): exceglan, excegram, excegran, zonegran.
Formula: C8H8N2O3S
IUPAC Formula: 1,2-Benzoxazol-3-Ylmethanesulfonamide
PDB name: 1-(1,2-Benzoxazol-3-Yl)methanesulfonamide

31
There are 31 target proteins defined in DrugBank for this drug.
 17 
17 of these target proteins have one or more structures in the PDB.
 1 
There is 1 PDB structure of the drug molecule bound to its target protein.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q9NY72 (SCN3B_HUMAN)  -  Sodium channel subunit beta-3
UniProt id: Q9NY72    214 a.a.  
4l1d A,B,C     113 a.a. 110   X-ray 2.50 Å
There are no PDB entries containing zonisamide bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: Q8IWT1 (SCN4B_HUMAN)  -  Sodium channel subunit beta-4
UniProt id: Q8IWT1    227 a.a.  
1. 4mz3 A,B     119 a.a. 117   X-ray 1.74 Å
  2. 4mz2 A     111 a.a. 110   X-ray 1.72 Å
There are no PDB entries containing zonisamide bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: O43497 (CAC1G_HUMAN)  -  Voltage-dependent T-type calcium channel subunit alpha-1G
UniProt id: O43497    2377 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: O95180 (CAC1H_HUMAN)  -  Voltage-dependent T-type calcium channel subunit alpha-1H
UniProt id: O95180    2353 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: Q9P0X4 (CAC1I_HUMAN)  -  Voltage-dependent T-type calcium channel subunit alpha-1I
UniProt id: Q9P0X4    2223 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: P00915 (CAH1_HUMAN)  -  Carbonic anhydrase 1
UniProt id: P00915    260 a.a.  
1. 1bzm A     260 a.a. 260   X-ray 2.00 Å
  2. 1czm A     260 a.a. 260   X-ray 2.00 Å
  3. 2nmx A,B     258 a.a. 258   X-ray 1.55 Å
  4. 1hcb A     258 a.a. 258   X-ray 1.60 Å
  5. 2nn1 A,B     258 a.a. 258   X-ray 1.65 Å
   more ...
There are no PDB entries containing zonisamide bound to this target protein, although there are 19 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 7:   UniProt id: P00918 (CAH2_HUMAN)  -  Carbonic anhydrase 2
UniProt id: P00918    259 a.a.  
1. 1lug A     259 a.a. 259   X-ray
  2. 2qo8 A     259 a.a. 259   X-ray 1.40 Å
  3. 3igp A     259 a.a. 259   X-ray 1.65 Å
  4. 3sbh A     259 a.a. 259   X-ray 1.65 Å
  5. 1can A     259 a.a. 259   X-ray 1.90 Å
   more ...
There are no PDB entries containing zonisamide bound to this target protein, although there are 479 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 8:   UniProt id: P07451 (CAH3_HUMAN)  -  Carbonic anhydrase 3
UniProt id: P07451    259 a.a.  
1. 2hfx A     259 a.a. 255   X-ray 1.70 Å
  2. 3uyq A     259 a.a. 255   X-ray 1.70 Å
  3. 2hfy A     259 a.a. 255   X-ray 2.60 Å
  4. 3uyn A     259 a.a. 255   X-ray 2.60 Å
  5. 1z93 A     263 a.a. 254   X-ray 2.10 Å
   more ...
There are no PDB entries containing zonisamide bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 9:   UniProt id: P22748 (CAH4_HUMAN)  -  Carbonic anhydrase 4
UniProt id: P22748    311 a.a.  
1. 1znc A     262 a.a. 262   X-ray 2.80 Å
  2. 3f7b A,B     257 a.a. 257   X-ray 2.05 Å
  3. 3fw3 A,B     249 a.a. 249   X-ray 1.72 Å
  4. 3f7u A,B,C,D     247 a.a. 247   X-ray 2.00 Å
There are no PDB entries containing zonisamide bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 10:   UniProt id: P35218 (CAH5A_HUMAN)  -  Carbonic anhydrase 5A, mitochondrial
UniProt id: P35218    305 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 11:   UniProt id: P35498 (SCN1A_HUMAN)  -  Sodium channel protein type 1 subunit alpha
UniProt id: P35498    2009 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 12:   UniProt id: Q9Y2D0 (CAH5B_HUMAN)  -  Carbonic anhydrase 5B, mitochondrial
UniProt id: Q9Y2D0    317 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 13:   UniProt id: P23280 (CAH6_HUMAN)  -  Carbonic anhydrase 6
UniProt id: P23280    307 a.a.  
3fe4 A,B     244 a.a. 244   X-ray 1.90 Å
There are no PDB entries containing zonisamide bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 14:   UniProt id: P43166 (CAH7_HUMAN)  -  Carbonic anhydrase 7
UniProt id: P43166    263 a.a.  
1. 3ml5 A     262 a.a. 260   X-ray 2.05 Å
  2. 3mdz A     259 a.a. 258   X-ray 2.32 Å
There are no PDB entries containing zonisamide bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 15:   UniProt id: P35219 (CAH8_HUMAN)  -  Carbonic anhydrase-related protein
UniProt id: P35219    289 a.a.  
2w2j A     268 a.a. 268   X-ray 1.60 Å
There are no PDB entries containing zonisamide bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 16:   UniProt id: Q16790 (CAH9_HUMAN)  -  Carbonic anhydrase 9
UniProt id: Q16790    458 a.a.  
3iai A,B,C,D     257 a.a. 255   X-ray 2.20 Å
There are no PDB entries containing zonisamide bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 17:   UniProt id: Q9NS85 (CAH10_HUMAN)  -  Carbonic anhydrase-related protein 10
UniProt id: Q9NS85    328 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 18:   UniProt id: O75493 (CAH11_HUMAN)  -  Carbonic anhydrase-related protein 11
UniProt id: O75493    328 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 19:   UniProt id: O43570 (CAH12_HUMAN)  -  Carbonic anhydrase 12
UniProt id: O43570    353 a.a.  
1. 4kp5 A,B,C,D     261 a.a. 261   X-ray 1.45 Å
  2. 4kp8 A,B,C,D     261 a.a. 261   X-ray 1.80 Å
  3. 1jd0 A,B     260 a.a. 260   X-ray 1.50 Å
  4. 1jcz A,B     260 a.a. 260   X-ray 1.55 Å
There are no PDB entries containing zonisamide bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 20:   UniProt id: Q8N1Q1 (CAH13_HUMAN)  -  Carbonic anhydrase 13
UniProt id: Q8N1Q1    261 a.a.  
1. 3d0n A,B     263 a.a. 261   X-ray 1.55 Å
  2. 3da2 A,B     262 a.a. 260   X-ray 2.05 Å
  3. 4knm A,B     259 a.a. 259   X-ray 1.90 Å
  4. 4knn B,A     258 a.a. 258   X-ray 1.40 Å
  5. 3czv A,B     258 a.a. 258   X-ray 2.00 Å
There are no PDB entries containing zonisamide bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 21:   UniProt id: Q9ULX7 (CAH14_HUMAN)  -  Carbonic anhydrase 14
UniProt id: Q9ULX7    336 a.a.  
4lu3 A     266 a.a. 266   X-ray 2.00 Å
There are no PDB entries containing zonisamide bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 22:   UniProt id: Q99250 (SCN2A_HUMAN)  -  Sodium channel protein type 2 subunit alpha
UniProt id: Q99250    2004 a.a.  
1. 4jpz B,H     142 a.a. 142   X-ray 3.02 Å
  2. 2kav A     106 a.a. 106   NMR  
There are no PDB entries containing zonisamide bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 23:   UniProt id: P27338 (AOFB_HUMAN)  -  Amine oxidase [flavin-containing] B
UniProt id: P27338    519 a.a.  
3po7 A,B   499 a.a. 499   X-ray 1.80 Å
The PDB contains 1 entry of zonisamide bound to this target protein and 41 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 24:   UniProt id: P21397 (AOFA_HUMAN)  -  Amine oxidase [flavin-containing] A
UniProt id: P21397    526 a.a.  
1. 2z5x A     513 a.a. 513   X-ray 2.20 Å
  2. 2z5y A     513 a.a. 512   X-ray 2.17 Å
  3. 2bxs A,B     490 a.a. 490   X-ray 3.15 Å
  4. 1h8q A     455 a.a. 455   Theor. model
  5. 2bxr A,B     445 a.a. 445   X-ray 3.00 Å
There are no PDB entries containing zonisamide bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 25:   UniProt id: Q9NY46 (SCN3A_HUMAN)  -  Sodium channel protein type 3 subunit alpha
UniProt id: Q9NY46    2000 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 26:   UniProt id: P35499 (SCN4A_HUMAN)  -  Sodium channel protein type 4 subunit alpha
UniProt id: P35499    1836 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 27:   UniProt id: Q14524 (SCN5A_HUMAN)  -  Sodium channel protein type 5 subunit alpha
UniProt id: Q14524    2015 a.a.  
1. 4dck A     153 a.a. 153   X-ray 2.20 Å
  2. 4jq0 D     142 a.a. 142   X-ray 3.84 Å
  3. 2kbi A     97 a.a. 93   NMR  
  4. 2l53 B     31 a.a. 27   NMR  
  5. 4djc B     13 a.a. 11   X-ray 1.35 Å
There are no PDB entries containing zonisamide bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 28:   UniProt id: Q15858 (SCN9A_HUMAN)  -  Sodium channel protein type 9 subunit alpha
UniProt id: Q15858    1988 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 29:   UniProt id: Q9UI33 (SCNBA_HUMAN)  -  Sodium channel protein type 11 subunit alpha
UniProt id: Q9UI33    1791 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 30:   UniProt id: Q07699 (SCN1B_HUMAN)  -  Sodium channel subunit beta-1
UniProt id: Q07699    218 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 31:   UniProt id: O60939 (SCN2B_HUMAN)  -  Sodium channel subunit beta-2
UniProt id: O60939    215 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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