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DB00880 : chlorothiazide

Approved drug chlorothiazide ... 4 targets DB00880

Generic name: chlorothiazide
 
Brand name(s): azide, chlotride, clotride, diuril, saluric.
Formula: C7H6Cln3O4S2
IUPAC Formula: 6-Chloro-1,1-Dioxo-4h-1l^{6},2,4-Benzothiadiazine-7-Sulfonamide

4
There are 4 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P55017 (S12A3_HUMAN)  -  Solute carrier family 12 member 3
UniProt id: P55017    1021 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P00915 (CAH1_HUMAN)  -  Carbonic anhydrase 1
UniProt id: P00915    260 a.a.  
1. 1bzm A     260 a.a. 260   X-ray 2.00 Å
  2. 1czm A     260 a.a. 260   X-ray 2.00 Å
  3. 2nmx A,B     258 a.a. 258   X-ray 1.55 Å
  4. 1hcb A     258 a.a. 258   X-ray 1.60 Å
  5. 2nn1 A,B     258 a.a. 258   X-ray 1.65 Å
   more ...
There are no PDB entries containing chlorothiazide bound to this target protein, although there are 19 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P00918 (CAH2_HUMAN)  -  Carbonic anhydrase 2
UniProt id: P00918    259 a.a.  
1. 1lug A     259 a.a. 259   X-ray
  2. 2qo8 A     259 a.a. 259   X-ray 1.40 Å
  3. 3igp A     259 a.a. 259   X-ray 1.65 Å
  4. 3sbh A     259 a.a. 259   X-ray 1.65 Å
  5. 1can A     259 a.a. 259   X-ray 1.90 Å
   more ...
There are no PDB entries containing chlorothiazide bound to this target protein, although there are 479 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P22748 (CAH4_HUMAN)  -  Carbonic anhydrase 4
UniProt id: P22748    311 a.a.  
1. 1znc A     262 a.a. 262   X-ray 2.80 Å
  2. 3f7b A,B     257 a.a. 257   X-ray 2.05 Å
  3. 3fw3 A,B     249 a.a. 249   X-ray 1.72 Å
  4. 3f7u A,B,C,D     247 a.a. 247   X-ray 2.00 Å
There are no PDB entries containing chlorothiazide bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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