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DB00869 : dorzolamide

Approved drug dorzolamide ... 3 targets DB00869

Generic name: dorzolamide PDB Het Group: ETS
 
5 structures in PDB
Brand name(s): trusopt.
Formula: C10H16N2O4S3
IUPAC Formula: (2s,4s)-4-(Ethylamino)-2-Methyl-1,1-Dioxo-2h,3h,4h-1l^{6},7-Thieno[2,3-B][1l^{6}]thiopyran-6-
Sulfonamide
PDB name: (4s-Trans)-4-(Ethylamino)-5,6-Dihydro-6-Methyl-4h-Thieno(2,3-B)thiopyran-2-Sulfonamide-7,7-Dioxide

3
There are 3 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
 5 
There are 5 PDB structures of the drug molecule bound to its target protein.
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Target proteins

DrugBank drug Target 1:   UniProt id: P00918 (CAH2_HUMAN)  -  Carbonic anhydrase 2
UniProt id: P00918    259 a.a.  
1. 4m2u A   257 a.a. 257   X-ray 2.00 Å
  2. 1cil A   256 a.a. 256   X-ray 1.60 Å
  3. 4k13 A   257 a.a. 252   X-ray 1.60 Å
  4. 4m2w A   257 a.a. 250   X-ray 1.66 Å
The PDB contains 4 entries of dorzolamide bound to this target protein and 479 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 2:   UniProt id: P22748 (CAH4_HUMAN)  -  Carbonic anhydrase 4
UniProt id: P22748    311 a.a.  
3fw3 A,B   249 a.a. 249   X-ray 1.72 Å
The PDB contains 1 entry of dorzolamide bound to this target protein and 4 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 3:   UniProt id: P00915 (CAH1_HUMAN)  -  Carbonic anhydrase 1
UniProt id: P00915    260 a.a.  
1. 1bzm A     260 a.a. 260   X-ray 2.00 Å
  2. 1czm A     260 a.a. 260   X-ray 2.00 Å
  3. 2nmx A,B     258 a.a. 258   X-ray 1.55 Å
  4. 1hcb A     258 a.a. 258   X-ray 1.60 Å
  5. 2nn1 A,B     258 a.a. 258   X-ray 1.65 Å
   more ...
There are no PDB entries containing dorzolamide bound to this target protein, although there are 19 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

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