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DB00862 : vardenafil

Approved drug vardenafil ... 3 targets DB00862

Generic name: vardenafil PDB Het Group: VDN
 
4 structures in PDB
Brand name(s): levitra.
Formula: C23H32N6O4S
IUPAC Formula: 2-[2-Ethoxy-5-(4-Ethylpiperazine-1-Sulfonyl)phenyl]-5-Methyl-7-Propyl-1h,4h-Imidazo[4,3-
F][1,2,4]triazin-4-One
PDB name: 2-{2-Ethoxy-5-[(4-Ethylpiperazin-1-Yl)sulfonyl]phenyl}-5-Methyl-7-Propylimidazo[5,1-
F][1,2,4]triazin-4(1h)-One

3
There are 3 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
 3 
There are 3 PDB structures of the drug molecule bound to its target protein.
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Target proteins

DrugBank drug Target 1:   UniProt id: O76074 (PDE5A_HUMAN)  -  CGMP-specific 3',5'-cyclic phosphodiesterase
UniProt id: O76074    874 a.a.  
1. 1uho A   313 a.a. 313   X-ray 2.50 Å
  2. 1xp0 A   326 a.a. 308   X-ray 1.79 Å
  3. 3b2r A,B   297 a.a. 293   X-ray 2.07 Å
The PDB contains 3 entries of vardenafil bound to this target protein and 34 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 2:   UniProt id: P18545 (CNRG_HUMAN)  -  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
UniProt id: P18545    87 a.a.  
   more ...
There are no PDB entries containing vardenafil bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 3:   UniProt id: Q13956 (CNCG_HUMAN)  -  Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma
UniProt id: Q13956    83 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

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