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DB00850 : perphenazine

Approved drug perphenazine ... 3 targets DB00850

Generic name: perphenazine
 
Brand name(s): apo-perphenazine, decentan, emesinal, f-mon, fentazin, perphenan, thilatazin, trifaron, trilafon, trilifan, triphenot.
Formula: C21H26Cln3Os
IUPAC Formula: 2-{4-[3-(2-Chloro-10h-Phenothiazin-10-Yl)propyl]piperazin-1-Yl}ethan-1-Ol

3
There are 3 target proteins defined in DrugBank for this drug.
 3 
3 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P14416 (DRD2_HUMAN)  -  D(2) dopamine receptor
UniProt id: P14416    442 a.a.  
1. 1i15 A     25 a.a. 25   Theor. model
  2. 2you B,C     14 a.a. 13   X-ray 2.19 Å
There are no PDB entries containing perphenazine bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P21728 (DRD1_HUMAN)  -  D(1A) dopamine receptor
UniProt id: P21728    445 a.a.  
1oz5 A     322 a.a. 322   Theor. model
There are no PDB entries containing perphenazine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 3:   UniProt id: P62158 (CALM_HUMAN)  -  Calmodulin
UniProt id: P62158    148 a.a.  
1. 4djc A     151 a.a. 148   X-ray 1.35 Å
  2. 2jzi A     148 a.a. 148   NMR  
  3. 2k0e A     148 a.a. 148   NMR  
  4. 2kne A     148 a.a. 148   NMR  
  5. 2l53 A     148 a.a. 148   NMR  
   more ...
There are no PDB entries containing perphenazine bound to this target protein, although there are 88 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

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