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DB00837 : progabide

Approved drug progabide ... 2 targets DB00837

Generic name: progabide
 
Brand name(s): gabren, gabrene.
Formula: C17H16Clfn2O2
IUPAC Formula: 4-{[(4-Chlorophenyl)[(1e)-3-Fluoro-6-Oxocyclohexa-2,4-Dien-1-Ylidene]methyl]amino}butanamide

2
There are 2 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: Q9UBS5 (GABR1_HUMAN)  -  Gamma-aminobutyric acid type B receptor, subunit 1
UniProt id: Q9UBS5    960 a.a.  
1. 4mr7 A     407 a.a. 404   X-ray 2.15 Å
  2. 4mr8 A     407 a.a. 404   X-ray 2.15 Å
  3. 4mqf A     406 a.a. 404   X-ray 2.22 Å
  4. 4ms1 A     407 a.a. 404   X-ray 2.25 Å
  5. 4mqe A     409 a.a. 404   X-ray 2.35 Å
   more ...
There are no PDB entries containing progabide bound to this target protein, although there are 10 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P14867 (GBRA1_HUMAN)  -  Gamma-aminobutyric-acid receptor subunit alpha-1
UniProt id: P14867    456 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

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