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DB00836 : loperamide

Approved drug loperamide ... 6 targets DB00836

Generic name: loperamide
 
Brand name(s): apo-loperamide, diarr-eze, imodium, imodium a-d, imodium a-d caplets, ioperamide, kaopectate ii, loperacap, loperamida [inn-spanish], loperamide hcl, loperamidum [inn-latin], maalox anti-diarrheal, nu-loperamide, pms-loperamide, pepto diarrhea control, rho-loperamide.
Formula: C29H33Cln2O2
IUPAC Formula: 4-[4-(4-Chlorophenyl)-4-Hydroxypiperidin-1-Yl]-N,N-Dimethyl-2,2-Diphenylbutanamide

6
There are 6 target proteins defined in DrugBank for this drug.
 4 
4 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P35372 (OPRM_HUMAN)  -  Mu-type opioid receptor
UniProt id: P35372    400 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 2:   UniProt id: P41143 (OPRD_HUMAN)  -  Delta-type opioid receptor
UniProt id: P41143    371 a.a.  
1ozc A     268 a.a. 268   Theor. model
There are no PDB entries containing loperamide bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P41145 (OPRK_HUMAN)  -  Kappa-type opioid receptor
UniProt id: P41145    379 a.a.  
2a0d A     380 a.a. 378   Theor. model
There are no PDB entries containing loperamide bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: O00555 (CAC1A_HUMAN)  -  Voltage-dependent P/Q-type calcium channel subunit alpha-1A
UniProt id: O00555    2504 a.a.  
3bxk B     17 a.a. 17   X-ray 2.55 Å
There are no PDB entries containing loperamide bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 5:   UniProt id: P01189 (COLI_HUMAN)  -  Corticotropin-lipotropin
UniProt id: P01189    267 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: P62158 (CALM_HUMAN)  -  Calmodulin
UniProt id: P62158    148 a.a.  
1. 4djc A     151 a.a. 148   X-ray 1.35 Å
  2. 2jzi A     148 a.a. 148   NMR  
  3. 2k0e A     148 a.a. 148   NMR  
  4. 2kne A     148 a.a. 148   NMR  
  5. 2l53 A     148 a.a. 148   NMR  
   more ...
There are no PDB entries containing loperamide bound to this target protein, although there are 84 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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