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DB00834 : mifepristone

Approved drug mifepristone ... 2 targets DB00834

Generic name: mifepristone PDB Het Group: 486
 
5 structures in PDB
Brand name(s): corlux, korlym, mifegyne, mifeprex.
Formula: C29H35No2
IUPAC Formula: (10s,11s,14s,15s,17r)-17-[4-(Dimethylamino)phenyl]-14-Hydroxy-15-Methyl-14-(Prop-1-Yn-1-
Yl)tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-1,6-Dien-5-One
PDB name: 11-(4-Dimethylamino-Phenyl)-17-Hydroxy-13-Methyl-17-Prop-1-Ynyl-1,2,6,7,8,11,12,13,14,15,16,17-
Dodec ahydro-Cyclopenta[a]phenanthren-3-One

2
There are 2 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
 4 
There are 4 PDB structures of the drug molecule bound to its target protein.
 1 
There is 1 PDB structure containing the drug molecule bound to a protein that is not specified as a target.
Links  
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Information  
Pharmacology
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Target proteins

DrugBank drug Target 1:   UniProt id: P06401 (PRGR_HUMAN)  -  Progesterone receptor
UniProt id: P06401    932 a.a.  
2w8y A,B   251 a.a. 251   X-ray 1.80 Å
The PDB contains 1 entry of mifepristone bound to this target protein and 20 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 2:   UniProt id: P04150 (GCR_HUMAN)  -  Glucocorticoid receptor
UniProt id: P04150    776 a.a.  
1. 3h52 A,B,C   247 a.a. 240   X-ray 2.80 Å
  2. 1nhz A   239 a.a. 237   X-ray 2.30 Å
The PDB contains 3 entries of mifepristone bound to this target protein and 16 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with mifepristone bound in the PDB

There is 1 "non-target" protein in the PDB containing the mifepristone molecule bound. That is, the UniProt code for the protein is missing or does not match any of the drug targets listed above.

Protein 1:   Ancestral ketosteroid receptor-progesterone-mifepristone com
  No Pfam domain assignments available for this protein.
4ltw A   251 a.a. 251   X-ray 2.04 Å

Key:    Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

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