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DB00831 : trifluoperazine

Approved drug trifluoperazine ... 6 targets DB00831

Generic name: trifluoperazine PDB Het Group: TFP
 
7 structures in PDB
Brand name(s): eskazine, eskazinyl, fluoperazine, jatroneural, modalina, novo-trifluzine, stelazine, stellazine, synklor, terfluzine, trazine, triflurin, triftazin, triftazine, triperazine, triphtazin, triphtazine, triphthasine, triphthazine, tryptazine.
Formula: C21H24F3N3S
IUPAC Formula: 10-[3-(4-Methylpiperazin-1-Yl)propyl]-2-(Trifluoromethyl)-10h-Phenothiazine
PDB name: 10-[3-(4-Methyl-Piperazin-1-Yl)-Propyl]-2-Trifluoromethyl-10h-Phenothiazine

6
There are 6 target proteins defined in DrugBank for this drug.
 4 
4 of these target proteins have one or more structures in the PDB.
 5 
There are 5 PDB structures of the drug molecule bound to its target protein.
 3 
There are 3 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P14416 (DRD2_HUMAN)  -  D(2) dopamine receptor
UniProt id: P14416    442 a.a.  
1. 1i15 A     25 a.a. 25   Theor. model
  2. 2you B,C     14 a.a. 13   X-ray 2.19 Å
There are no PDB entries containing trifluoperazine bound to this target protein, although there are 2 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: Q9NYX4 (CALY_HUMAN)  -  D1 dopamine receptor-interacting protein calcyon
UniProt id: Q9NYX4    217 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P35348 (ADA1A_HUMAN)  -  Alpha-1A adrenergic receptor
UniProt id: P35348    466 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P62158 (CALM_HUMAN)  -  Calmodulin
UniProt id: P62158    148 a.a.  
1ctr A   142 a.a. 142   X-ray 2.45 Å
The PDB contains 1 entry of trifluoperazine bound to this target protein and 90 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 5:   UniProt id: P63316 (TNNC1_HUMAN)  -  Troponin C, slow skeletal and cardiac muscles
UniProt id: P63316    160 a.a.  
1. 1wrk A,B   82 a.a. 80   X-ray 2.15 Å
  2. 1wrl A,B,C,D,...   82 a.a. 80   X-ray 2.60 Å
The PDB contains 2 entries of trifluoperazine bound to this target protein and 30 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 6:   UniProt id: P26447 (S10A4_HUMAN)  -  Protein S100-A4
UniProt id: P26447    100 a.a.  
3ko0 A,B,C,D,...   93 a.a. 93   X-ray 2.30 Å
The PDB contains 2 entries of trifluoperazine bound to this target protein and 12 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with trifluoperazine bound in the PDB

There are 2 "non-target" proteins in the PDB containing the trifluoperazine molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P62157 ()  -  Calmodulin OS=Bos taurus GN=CALM PE=1 SV=2
UniProt id: P62157    148 a.a.  
1. 1lin A   146 a.a. 146   X-ray 2.00 Å
  2. 1a29 A   144 a.a. 144   X-ray 2.74 Å
The PDB contains 2 entries of trifluoperazine bound to this protein
Protein 2:   Calcium binding protein
  No Pfam domain assignments available for this protein.
2cln     148 a.a. 148   Theor. model

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

Where there is more than one PDB model for a given UniProt sequence, the models are ordered by: 1. decreasing order of similarity to the UniProt sequence, 2. X-ray structures (in order of increasing resolution), NMR structures, and theoretical models. Clicking on any PDB code take you to the corresponding PDBsum page.

 

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