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DB00828 : fosfomycin

Approved drug fosfomycin ... 1 target DB00828

Generic name: fosfomycin PDB Het Group: FCN
 
12 structures in PDB
Brand name(s): veramina.
Formula: C3H7O4P
IUPAC Formula: [(2r,3s)-3-Methyloxiran-2-Yl]phosphonic acid
PDB name: Fosfomycin

1
There is 1 target protein defined in DrugBank for this drug.
 1 
The target protein has one or more structures in the PDB.
 12 
There are 12 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Target proteins

DrugBank drug Target 1:   UniProt id: P0A749 (MURA_ECOLI)  -  UDP-N-acetylglucosamine 1-carboxyvinyltransferase
UniProt id: P0A749    418 a.a.  
1. 1uae A     418 a.a. 417   X-ray 1.80 Å
  2. 3kqj A     418 a.a. 416   X-ray 1.70 Å
  3. 3kr6 A     418 a.a. 416   X-ray 1.70 Å
  4. 3iss A,B,C,D,...     418 a.a. 416   X-ray 2.50 Å
  5. 1a2n A     418 a.a. 416   X-ray 2.80 Å
   more ...
There are no PDB entries containing fosfomycin bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with fosfomycin bound in the PDB

There are 5 "non-target" proteins in the PDB containing the fosfomycin molecule bound. That is, the UniProt code for the proteins is missing or does not match the drug target above.

Protein 1:   UniProt id: Q56185 ()  -  (S)-2-hydroxypropylphosphonic acid epoxidase OS=Streptomyces wedmorensis GN=hppE PE=1 SV=1
UniProt id: Q56185    197 a.a.  
2bnn A,B   194 a.a. 194   X-ray 2.50 Å
The PDB contains 1 entry of fosfomycin bound to this protein
Protein 2:   UniProt id: Q56187 ()  -  FomA protein OS=Streptomyces wedmorensis GN=fomA PE=1 SV=2
UniProt id: Q56187    266 a.a.  
1. 3d41 A   268 a.a. 258   X-ray 2.20 Å
  2. 3quo A   265 a.a. 252   X-ray 1.58 Å
The PDB contains 2 entries of fosfomycin bound to this protein
Protein 3:   UniProt id: Q739M9 ()  -  Metallothiol transferase FosB OS=Bacillus cereus (strain ATCC 10987) GN=fosB PE=1 SV=1
UniProt id: Q739M9    137 a.a.  
1. 4jh6 A,B   138 a.a. 137   X-ray 1.32 Å
  2. 4jh8 A,B   138 a.a. 137   X-ray 1.41 Å
  3. 4jh3 A,B   138 a.a. 137   X-ray 1.50 Å
  4. 4jh5 A,B   138 a.a. 137   X-ray 1.77 Å
  5. 4jh4 A,B   138 a.a. 137   X-ray 1.90 Å
The PDB contains 5 entries of fosfomycin bound to this protein
Protein 4:   UniProt id: Q81W73 ()  -  Metallothiol transferase FosB 2 OS=Bacillus anthracis GN=fosB2 PE=1 SV=1
UniProt id: Q81W73    138 a.a.  
1. 3uh9 A   144 a.a. 138   X-ray 1.60 Å
  2. 4ir0 A   147 a.a. 138   X-ray 1.60 Å
  3. 4jd1 A,B   147 a.a. 138   X-ray 1.70 Å
The PDB contains 3 entries of fosfomycin bound to this protein
Protein 5:   UniProt id: Q9I4K6 ()  -  Glutathione transferase FosA OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228) GN=fosA PE=1 SV=1
UniProt id: Q9I4K6    134 a.a.  
1lqp A,B   134 a.a. 133   X-ray 1.19 Å
The PDB contains 1 entry of fosfomycin bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

Where there is more than one PDB model for a given UniProt sequence, the models are ordered by: 1. decreasing order of similarity to the UniProt sequence, 2. X-ray structures (in order of increasing resolution), NMR structures, and theoretical models. Clicking on any PDB code take you to the corresponding PDBsum page.

 

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