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DB00824 : enprofylline

Approved drug enprofylline ... 3 targets DB00824

Generic name: enprofylline
 
Brand name(s): nilyph, oxeze.
Formula: C8H10N4O2
IUPAC Formula: 3-Propyl-2,3,6,7-Tetrahydro-1h-Purine-2,6-Dione

3
There are 3 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P27815 (PDE4A_HUMAN)  -  CAMP-specific 3',5'-cyclic phosphodiesterase 4A
UniProt id: P27815    885 a.a.  
1. 2qyk A,B     334 a.a. 333   X-ray 2.10 Å
  2. 3tvx A,B     334 a.a. 333   X-ray 2.84 Å
  3. 3i8v A,B     334 a.a. 331   X-ray 2.25 Å
There are no PDB entries containing enprofylline bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: Q07343 (PDE4B_HUMAN)  -  CAMP-specific 3',5'-cyclic phosphodiesterase 4B
UniProt id: Q07343    735 a.a.  
1. 3g45 A,B     371 a.a. 371   X-ray 2.63 Å
  2. 3hmv A,B     351 a.a. 350   X-ray 2.23 Å
  3. 1f0j A,B     351 a.a. 349   X-ray 1.77 Å
  4. 1jp1 A     351 a.a. 349   Theor. model
  5. 1jp2 A     351 a.a. 349   Theor. model
   more ...
There are no PDB entries containing enprofylline bound to this target protein, although there are 36 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P29275 (AA2BR_HUMAN)  -  Adenosine A2b receptor
UniProt id: P29275    332 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

Structure selection

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