spacer
spacer

Search 

DB00822 : disulfiram

Approved drug disulfiram ... 2 targets DB00822

Generic name: disulfiram
 
Brand name(s): abstensil, abstinil, abstinyl, accel tet, accel tet-r, akrochem tetd, alcophobin, alk-aubs, ancazide et, antabus, antabuse, antadix, antaenyl, antaethan, antaethyl, antaetil, antalcol, antetan, antethyl, antetil, anteyl, anthethyl, anti-ethyl, antiaethan, anticol, antietanol, antietil, antikol, antivitium, aversan, averzan, bonibal, contralin, contrapot, cronetal, dicupral, disetil, disulfan, disulfram, ekagom dtet, ekagom teds, ekagom tetds, ekaland tetd, ephorran, espenal, esperal, etabus, ethyl thiram, ethyl thiudad, ethyl thiurad, ethyl tuads, ethyl tuads rodform, ethyl tuex, ethyldithiourame, ethyldithiurame, etyl tuex, exhoran, exhorran, gababentin, hoca, krotenal, nocbin, nocceler tet, nocceler tet-g, noxal, perkacit tetd, perkait tetd, refusal, ro-sulfiram, sanceler tet, sanceler tet-g, soxinol tet, stopaethyl, stopethyl, stopety, stopetyl, super rodiatox, tts, tts x, tenurid, tenutex, tetidis, tetradin, tetradine, tetraetil, teturam, teturamin, thiocid, thiophos, thireranide, tillram, tiuram.
Formula: C10H20N2S4
IUPAC Formula: N,N-Diethyl[(diethylcarbamothioyl)disulfanyl]carbothioamide

2
There are 2 target proteins defined in DrugBank for this drug.
 1 
1 of these target proteins has one or more structures in the PDB.
Links  
DrugBank
RxList
ChEBI
KEGG drug
PubChem
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: P05091 (ALDH2_HUMAN)  -  Aldehyde dehydrogenase, mitochondrial
UniProt id: P05091    516 a.a.  
1. 3inj A,B,C,D,...     494 a.a. 494   X-ray 1.69 Å
  2. 1o02 A,B,C,D,...     494 a.a. 494   X-ray 1.90 Å
  3. 3sz9 A,B,C,D,...     494 a.a. 494   X-ray 2.10 Å
  4. 4kwg A,B,C,D,...     494 a.a. 494   X-ray 2.10 Å
  5. 1o01 A,B,C,D,...     494 a.a. 494   X-ray 2.15 Å
   more ...
There are no PDB entries containing disulfiram bound to this target protein, although there are 27 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P09172 (DOPO_HUMAN)  -  Dopamine beta-hydroxylase
UniProt id: P09172    617 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer

  spacer

spacer