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DB00819 : acetazolamide

Approved drug acetazolamide ... 7 targets DB00819

Generic name: acetazolamide PDB Het Group: AZM
 
24 structures in PDB
Brand name(s): acetamox, acetazolam, ak-zol, apo-acetazolamide, atenezol, cidamex, dazamide, defiltran, dehydratin, diacarb, diakarb, diamox, diamox sequels, didoc, diluran, diuramid, diureticum-holzinger, diuriwas, diutazol, donmox, duiramid, edemox, eumicton, fonurit, glaupax, glupax, natrionex, nephramid, nephramide, phonurit, sk-acetazolamide, storzolamide, vetamox.
Formula: C4H6N4O3S2
IUPAC Formula: N-(5-Sulfamoyl-1,3,4-Thiadiazol-2-Yl)acetamide
PDB name: 5-Acetamido-1,3,4-Thiadiazole-2-Sulfonamide

7
There are 7 target proteins defined in DrugBank for this drug.
 7 
7 of these target proteins have one or more structures in the PDB.
 15 
There are 15 PDB structures of the drug molecule bound to its target protein.
 9 
There are 9 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
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Information  
Pharmacology
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Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: P00915 (CAH1_HUMAN)  -  Carbonic anhydrase 1
UniProt id: P00915    260 a.a.  
1. 1azm A   258 a.a. 258   X-ray 2.00 Å
  2. 3w6h A,B   256 a.a. 256   X-ray 2.96 Å
The PDB contains 2 entries of acetazolamide bound to this target protein and 19 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 2:   UniProt id: Q9ULX7 (CAH14_HUMAN)  -  Carbonic anhydrase 14
UniProt id: Q9ULX7    336 a.a.  
4lu3 A   266 a.a. 266   X-ray 2.00 Å
The PDB contains 1 entry of acetazolamide bound to this target protein
DrugBank drug Target 3:   UniProt id: P00918 (CAH2_HUMAN)  -  Carbonic anhydrase 2
UniProt id: P00918    259 a.a.  
1. 3hs4 A   257 a.a. 257   X-ray 1.10 Å
  2. 3v2m A   257 a.a. 257   X-ray 1.47 Å
  3. 3v2j A   257 a.a. 257   X-ray 1.70 Å
  4. 4g0c A   257 a.a. 257   Not given  
  5. 2h4n A   257 a.a. 256   X-ray 1.90 Å
   more ...
The PDB contains 11 entries of acetazolamide bound to this target protein and 479 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 4:   UniProt id: P07451 (CAH3_HUMAN)  -  Carbonic anhydrase 3
UniProt id: P07451    259 a.a.  
1. 2hfx A     259 a.a. 255   X-ray 1.70 Å
  2. 3uyq A     259 a.a. 255   X-ray 1.70 Å
  3. 2hfy A     259 a.a. 255   X-ray 2.60 Å
  4. 3uyn A     259 a.a. 255   X-ray 2.60 Å
  5. 1z93 A     263 a.a. 254   X-ray 2.10 Å
   more ...
There are no PDB entries containing acetazolamide bound to this target protein, although there are 7 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 5:   UniProt id: P22748 (CAH4_HUMAN)  -  Carbonic anhydrase 4
UniProt id: P22748    311 a.a.  
1. 1znc A     262 a.a. 262   X-ray 2.80 Å
  2. 3f7b A,B     257 a.a. 257   X-ray 2.05 Å
  3. 3fw3 A,B     249 a.a. 249   X-ray 1.72 Å
  4. 3f7u A,B,C,D     247 a.a. 247   X-ray 2.00 Å
There are no PDB entries containing acetazolamide bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 6:   UniProt id: P43166 (CAH7_HUMAN)  -  Carbonic anhydrase 7
UniProt id: P43166    263 a.a.  
3ml5 A   262 a.a. 260   X-ray 2.05 Å
The PDB contains 1 entry of acetazolamide bound to this target protein and 2 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 7:   UniProt id: P29972 (AQP1_HUMAN)  -  Aquaporin-1
UniProt id: P29972    268 a.a.  
1. 1fqy A     226 a.a. 226   Not given  
  2. 1h6i A     225 a.a. 225   Not given  
  3. 1hw0 A     224 a.a. 224   Not given  
  4. 1ih5 A     224 a.a. 224   Not given  
There are no PDB entries containing acetazolamide bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

 

Other proteins with acetazolamide bound in the PDB

There are 9 "non-target" proteins in the PDB containing the acetazolamide molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: B0Y2Y2 ()  -  Class III chitinase ChiA1 OS=Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) GN=AFUB_052270 PE=1 SV=1
UniProt id: B0Y2Y2    865 a.a.  
2xtk A,B   310 a.a. 309   X-ray 2.00 Å
The PDB contains 1 entry of acetazolamide bound to this protein
Protein 2:   UniProt id: B2V8E3 ()  -  Carbonate dehydratase OS=Sulfurihydrogenibium sp. (strain YO3AOP1) GN=SYO3AOP1_0578 PE=1 SV=1
UniProt id: B2V8E3    245 a.a.  
4g7a A,B   224 a.a. 224   X-ray 1.80 Å
The PDB contains 1 entry of acetazolamide bound to this protein
Protein 3:   UniProt id: O43570 ()  -  Carbonic anhydrase 12 OS=Homo sapiens GN=CA12 PE=1 SV=1
UniProt id: O43570    353 a.a.  
1jd0 A,B   260 a.a. 260   X-ray 1.50 Å
The PDB contains 1 entry of acetazolamide bound to this protein
Protein 4:   UniProt id: P23589 ()  -  Carbonic anhydrase 5A, mitochondrial OS=Mus musculus GN=Ca5a PE=1 SV=2
UniProt id: P23589    298 a.a.  
1dmy A,B   237 a.a. 235   X-ray 2.45 Å
The PDB contains 1 entry of acetazolamide bound to this protein
Protein 5:   UniProt id: P29029 ()  -  Endochitinase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CTS1 PE=1 SV=2
UniProt id: P29029    561 a.a.  
2uy4 A   284 a.a. 284   X-ray 1.75 Å
The PDB contains 1 entry of acetazolamide bound to this protein
Protein 6:   UniProt id: Q16790 ()  -  Carbonic anhydrase 9 OS=Homo sapiens GN=CA9 PE=1 SV=2
UniProt id: Q16790    458 a.a.  
3iai A,B,C,D   257 a.a. 255   X-ray 2.20 Å
The PDB contains 1 entry of acetazolamide bound to this protein
Protein 7:   UniProt id: Q8N1Q1 ()  -  Carbonic anhydrase 13 OS=Homo sapiens GN=CA13 PE=1 SV=1
UniProt id: Q8N1Q1    261 a.a.  
3czv A,B   258 a.a. 258   X-ray 2.00 Å
The PDB contains 1 entry of acetazolamide bound to this protein
Protein 8:   UniProt id: Q96554 ()  -  Carbonic anhydrase OS=Coccomyxa sp. PA PE=1 SV=1
UniProt id: Q96554    226 a.a.  
3ucj A,B   222 a.a. 222   X-ray 1.85 Å
The PDB contains 1 entry of acetazolamide bound to this protein
Protein 9:   UniProt id: Q9WVT6 ()  -  Carbonic anhydrase 14 OS=Mus musculus GN=Ca14 PE=1 SV=1
UniProt id: Q9WVT6    336 a.a.  
1rj6 A,B   259 a.a. 258   X-ray 2.90 Å
The PDB contains 1 entry of acetazolamide bound to this protein

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

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