spacer
spacer

Search 

DB00811 : ribavirin

Approved drug ribavirin ... 7 targets DB00811

Generic name: ribavirin PDB Het Group: RBV
 
2 structures in PDB
Brand name(s): copegus, ribav, rtc, rtca, rebetol, rebetron, rebretron, ribamide, ribamidil, ribamidyl, ribasphere, ribavirin capsules, ribavirin-tp, tribavirin, varazid, vilona, viramid, virazid, virazole.
Formula: C8H12N4O5
IUPAC Formula: 1-[(2r,3r,4s,5r)-3,4-Dihydroxy-5-(Hydroxymethyl)oxolan-2-Yl]-1h-1,2,4-Triazole-3-Carboxamide
PDB name: 1-(Beta-D-Ribofuranosyl)-1h-1,2,4-Triazole-3-Carboxamide

7
There are 7 target proteins defined in DrugBank for this drug.
 4 
4 of these target proteins have one or more structures in the PDB.
 2 
There are 2 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
Links  
DrugBank
RxList
KEGG drug
PubChem
MSDChem
Ligand Expo
HIC-Up
Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: P20839 (IMDH1_HUMAN)  -  Inosine-5'-monophosphate dehydrogenase 1
UniProt id: P20839    513 a.a.  
1jcn A,B     395 a.a. 393   X-ray 2.50 Å
There are no PDB entries containing ribavirin bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: P55263 (ADK_HUMAN)  -  Adenosine kinase
UniProt id: P55263    361 a.a.  
1. 1bx4 A     342 a.a. 341   X-ray 1.50 Å
  2. 2i6a A,B,C,D     343 a.a. 341   X-ray 2.20 Å
  3. 2i6b A,B     329 a.a. 326   X-ray 2.30 Å
  4. 4o1l A,B     326 a.a. 326   X-ray 2.50 Å
There are no PDB entries containing ribavirin bound to this target protein, although there are 4 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P26676 (L_PI2HT)  -  Large structural protein
UniProt id: P26676    2262 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 4:   UniProt id: P16502 (RDRP_I56A0)  -  RNA-directed RNA polymerase catalytic subunit
UniProt id: P16502    757 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   Bacterial outer membrane
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: P49902 (5NTC_HUMAN)  -  Cytosolic purine 5'-nucleotidase
UniProt id: P49902    560 a.a.  
1. 2j2c A     470 a.a. 470   X-ray 2.20 Å
  2. 2xcw A     470 a.a. 469   X-ray 1.90 Å
  3. 4h4b A     468 a.a. 468   X-ray 2.90 Å
  4. 2jc9 A     467 a.a. 467   X-ray 1.50 Å
  5. 2xcx A     467 a.a. 466   X-ray 2.30 Å
   more ...
There are no PDB entries containing ribavirin bound to this target protein, although there are 12 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 7:   UniProt id: P22413 (ENPP1_HUMAN)  -  Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
UniProt id: P22413    924 a.a.  
2ys0 A     56 a.a. 42   NMR  
There are no PDB entries containing ribavirin bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with ribavirin bound in the PDB

There are 2 "non-target" proteins in the PDB containing the ribavirin molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: Q80J95 ()  -  Polyprotein OS=Murine norovirus 1 PE=1 SV=2
UniProt id: Q80J95    1684 a.a.  
3sfu A,B,C   480 a.a. 480   X-ray 2.50 Å
The PDB contains 1 entry of ribavirin bound to this protein
Protein 2:   UniProt id: Q9KPL5 ()  -  NupC family protein OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) GN=VC_2352 PE=1 SV=1
UniProt id: Q9KPL5    417 a.a.  
4pb1 A   404 a.a. 402   X-ray 2.80 Å
The PDB contains 1 entry of ribavirin bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Structure selection

Use the checkboxes above to select the structure(s) of interest, and then press the required button below to view:
View 3D structure
Select preferred viewer and click on 3D struct button
AstexViewer™@MSD-EBI
RasMol
STRAP multiple alignment viewer
LIGPLOT diagrams
Press button below for LIGPLOT diagrams of drug-protein interactions in all selected structures above.

  spacer

spacer