DB00784 : mefenamic acid

Approved drug mefenamic acid ... 2 targets DB00784

Generic name: mefenamic acid PDB Het Group: ID8
4 structures in PDB
Brand name(s): bafameritin-m, bafhameritin-m, bonabol, coslan, hl 1, in-m, lysalgo, mefacit, namphen, parkemed, ponalar, ponstan, ponstan forte, ponstel, ponstil, ponstyl, pontal, tamany bonsan, tanston, vialidon.
Formula: C15H15No2
IUPAC Formula: 2-[(2,3-Dimethylphenyl)amino]benzoic acid
PDB name: 2-[(2,3-Dimethylphenyl)amino]benzoic acid

There are 2 target proteins defined in DrugBank for this drug.
1 of these target proteins has one or more structures in the PDB.
There are 3 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
KEGG drug
Ligand Expo


Target proteins

DrugBank drug Target 1:   UniProt id: P35354 (PGH2_HUMAN)  -  Prostaglandin G/H synthase 2
UniProt id: P35354    603 a.a.  
1v0x A     604 a.a. 603   Theor. model
There are no PDB entries containing mefenamic acid bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: P23219 (PGH1_HUMAN)  -  Prostaglandin G/H synthase 1
UniProt id: P23219    599 a.a.  
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule


Other proteins with mefenamic acid bound in the PDB

There are 3 "non-target" proteins in the PDB containing the mefenamic acid molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P05543 ()  -  Thyroxine-binding globulin OS=Homo sapiens GN=SERPINA7 PE=1 SV=2
UniProt id: P05543    414 a.a.  
2xn3 A   337 a.a. 328   X-ray 2.09 Å
The PDB contains 1 entry of mefenamic acid bound to this protein
Protein 2:   UniProt id: P24627 ()  -  Lactotransferrin OS=Bos taurus GN=LTF PE=1 SV=2
UniProt id: P24627    707 a.a.  
4g2z A   335 a.a. 333   X-ray 1.90 Å
The PDB contains 1 entry of mefenamic acid bound to this protein
Protein 3:   UniProt id: P52895 ()  -  Aldo-keto reductase family 1 member C2 OS=Homo sapiens GN=AKR1C2 PE=1 SV=3
UniProt id: P52895    322 a.a.  
4jqa A,B   316 a.a. 316   X-ray 1.45 Å
The PDB contains 1 entry of mefenamic acid bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.


Structure selection

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