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DB00780 : phenelzine

Approved drug phenelzine ... 7 targets DB00780

Generic name: phenelzine
 
Brand name(s): beta-phenylethylhydrazine, fenelzina [inn-spanish], fenelzyna, fenelzyne, phenelezine, phenelzinum [inn-latin], phenethylhydrazine, phenylethyl hydrazine-hcl, phenylethylhydrazine.
Formula: C8H12N2
IUPAC Formula: (2-Phenylethyl)hydrazine

7
There are 7 target proteins defined in DrugBank for this drug.
 4 
4 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P21397 (AOFA_HUMAN)  -  Amine oxidase [flavin-containing] A
UniProt id: P21397    526 a.a.  
1. 2z5x A     513 a.a. 513   X-ray 2.20 Å
  2. 2z5y A     513 a.a. 512   X-ray 2.17 Å
  3. 2bxs A,B     490 a.a. 490   X-ray 3.15 Å
  4. 1h8q A     455 a.a. 455   Theor. model
  5. 2bxr A,B     445 a.a. 445   X-ray 3.00 Å
There are no PDB entries containing phenelzine bound to this target protein, although there are 5 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P27338 (AOFB_HUMAN)  -  Amine oxidase [flavin-containing] B
UniProt id: P27338    519 a.a.  
1. 1s3e A,B     499 a.a. 499   X-ray 1.60 Å
  2. 2v5z A,B     499 a.a. 499   X-ray 1.60 Å
  3. 2xfn A,B     499 a.a. 499   X-ray 1.60 Å
  4. 1s3b A,B     499 a.a. 499   X-ray 1.65 Å
  5. 2xfp A,B     499 a.a. 499   X-ray 1.66 Å
   more ...
There are no PDB entries containing phenelzine bound to this target protein, although there are 41 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: Q16853 (AOC3_HUMAN)  -  Membrane copper amine oxidase
UniProt id: Q16853    762 a.a.  
1. 4btw A,B     710 a.a. 709   X-ray 2.80 Å
  2. 4bty A,B     710 a.a. 709   X-ray 3.10 Å
  3. 4btx A,B     708 a.a. 707   X-ray 2.78 Å
  4. 2c10 A,B,C,D     705 a.a. 703   X-ray 2.50 Å
  5. 2y73 A,B     704 a.a. 703   X-ray 2.60 Å
   more ...
There are no PDB entries containing phenelzine bound to this target protein, although there are 10 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P80404 (GABT_HUMAN)  -  4-aminobutyrate aminotransferase, mitochondrial
UniProt id: P80404    500 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 5:   UniProt id: P24298 (ALAT1_HUMAN)  -  Alanine aminotransferase 1
UniProt id: P24298    496 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 6:   UniProt id: Q8TD30 (ALAT2_HUMAN)  -  Alanine aminotransferase 2
UniProt id: Q8TD30    522 a.a.  
3ihj A     461 a.a. 454   X-ray 2.30 Å
There are no PDB entries containing phenelzine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 7:   UniProt id: Q9UGI5 (Q9UGI5_HUMAN)  -  Glutamic acid decarboxylase
UniProt id: Q9UGI5    419 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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