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DB00775 : tirofiban

Approved drug tirofiban ... 2 targets DB00775

Generic name: tirofiban PDB Het Group: AGG
 
2 structures in PDB
Brand name(s): agg, aggrastat, tirofiban [ban:inn].
Formula: C22H36N2O5S
IUPAC Formula: (2s)-2-(Butane-1-Sulfonamido)-3-{4-[4-(Piperidin-4-Yl)butoxy]phenyl}propanoic acid
PDB name: Tirofiban

2
There are 2 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
 4 
There are 4 PDB structures of the drug molecule bound to its target protein.
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Target proteins

DrugBank drug Target 1:   UniProt id: P08514 (ITA2B_HUMAN)  -  Integrin alpha-IIb
UniProt id: P08514    1038 a.a.  
1. 2vdm A   452 a.a. 452   X-ray 2.90 Å
  2. 1ty5 A   452 a.a. 451   X-ray 2.90 Å
The PDB contains 2 entries of tirofiban bound to this target protein and 41 entries of this target protein in all (click on orange, plus icon for list).
DrugBank drug Target 2:   UniProt id: P05106 (ITB3_HUMAN)  -  Integrin beta-3
UniProt id: P05106    787 a.a.  
1. 2vdm B   456 a.a. 456   X-ray 2.90 Å
  2. 1ty5 B   440 a.a. 440   X-ray 2.90 Å
The PDB contains 2 entries of tirofiban bound to this target protein and 58 entries of this target protein in all (click on orange, plus icon for list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

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