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DB00768 : olopatadine

Approved drug olopatadine ... 6 targets DB00768

Generic name: olopatadine
 
Brand name(s): olopatadine hydrochloride, patanol.
Formula: C21H23No3
IUPAC Formula: 2-[(2z)-2-[3-(Dimethylamino)propylidene]-9-Oxatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,12,14-
Hexaen-5-Yl]acetic acid

6
There are 6 target proteins defined in DrugBank for this drug.
 6 
6 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P35367 (HRH1_HUMAN)  -  Histamine H1 receptor
UniProt id: P35367    487 a.a.  
   more ...
There are no PDB entries containing olopatadine bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: P23297 (S10A1_HUMAN)  -  Protein S100-A1
UniProt id: P23297    93 a.a.  
1. 2l0p A,B     93 a.a. 93   NMR  
  2. 2llu A,B     93 a.a. 93   NMR  
  3. 2lp2 A,B     93 a.a. 93   NMR  
  4. 2lp3 A,B     93 a.a. 93   NMR  
  5. 2lhl A,B     93 a.a. 92   NMR  
   more ...
There are no PDB entries containing olopatadine bound to this target protein, although there are 9 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P80511 (S10AC_HUMAN)  -  Protein S100-A12
UniProt id: P80511    91 a.a.  
1. 2wcb A,B     92 a.a. 91   X-ray 1.73 Å
  2. 2m9g A,B     92 a.a. 91   NMR  
  3. 1odb A,B,C,D,...     91 a.a. 90   X-ray 2.19 Å
  4. 2wcf A,B,C,D,...     91 a.a. 90   X-ray 2.78 Å
  5. 2wce A,B     91 a.a. 89   X-ray 1.77 Å
   more ...
There are no PDB entries containing olopatadine bound to this target protein, although there are 8 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P04271 (S100B_HUMAN)  -  Protein S100-B
UniProt id: P04271    91 a.a.  
1. 3d10 A,B     92 a.a. 91   X-ray 1.65 Å
  2. 1mq1 A,B     91 a.a. 91   NMR  
  3. 1uwo A,B     91 a.a. 91   NMR  
  4. 2pru A,B     91 a.a. 91   NMR  
  5. 3czt X     91 a.a. 90   X-ray 1.40 Å
   more ...
There are no PDB entries containing olopatadine bound to this target protein, although there are 8 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 5:   UniProt id: Q99584 (S10AD_HUMAN)  -  Protein S100-A13
UniProt id: Q99584    97 a.a.  
1. 1yur A,B     98 a.a. 97   NMR  
  2. 1yus A,B     98 a.a. 97   NMR  
  3. 1yut A,B     98 a.a. 97   NMR  
  4. 1yuu A,B     98 a.a. 97   NMR  
  5. 2k8m B,C     98 a.a. 97   NMR  
   more ...
There are no PDB entries containing olopatadine bound to this target protein, although there are 12 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 6:   UniProt id: P29034 (S10A2_HUMAN)  -  Protein S100-A2
UniProt id: P29034    97 a.a.  
1. 2rgi A,B     93 a.a. 89   X-ray 1.60 Å
  2. 3n22 A,B     88 a.a. 85   X-ray 1.30 Å
  3. 4duq A,B     88 a.a. 85   X-ray 1.30 Å
There are no PDB entries containing olopatadine bound to this target protein, although there are 3 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

 

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