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DB00759 : tetracycline

Approved drug tetracycline ... 7 targets DB00759

Generic name: tetracycline PDB Het Group: TAC
 
11 structures in PDB
Brand name(s): abramycin, abricycline, achromycin, achromycin v, actisite, agromicina, ambramicina, ambramycin, amycin, bio-tetra, biocycline, bristaciclin, bristaciclina, bristacycline, cefracycline, ciclibion, copharlan, criseociclina, cyclopar, cytome, democracin, deschlorobiomycin, dumocyclin, enterocycline, hostacyclin, lexacycline, limecycline, medocycline, mericycline, micycline, neocycline, omegamycin, orlycycline, panmycin, polycycline, polyotic, purocyclina, resteclin, retet, robitet, roviciclina, sk-tetracycline, solvocin, sumycin, tetra-co, tetrabon, tetrachel, tetracycl, tetracycline ii, tetracyn, tetradecin, tetrafil, tetramed, tetraverine, tetrex, topicycline, tsiklomistsin, tsiklomitsin, veracin, vetacyclinum.
Formula: C22H24N2O8
IUPAC Formula: (4s,4as,5as,6s,12as)-4-(Dimethylamino)-3,6,10,12,12a-Pentahydroxy-6-Methyl-1,11-Dioxo-
1,4,4a,5,5a,6,11,12a-Octahydrotetracene-2-Carboxamide
PDB name: Tetracycline

7
There are 7 target proteins defined in DrugBank for this drug.
 6 
6 of these target proteins have one or more structures in the PDB.
 6 
There are 6 PDB structures containing the drug molecule bound to a protein that is not specified as a target.
Links  
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Information  
Pharmacology
Indication
Action

 

Target proteins

DrugBank drug Target 1:   UniProt id: P02359 (RS7_ECOLI)  -  30S ribosomal protein S7
UniProt id: P02359    178 a.a.  
1. 3izv K     178 a.a. 178   Not given  
  2. 3izw K     178 a.a. 178   Not given  
  3. 3j00 G     178 a.a. 178   Not given  
  4. 3j0u J     178 a.a. 178   Not given  
  5. 3j0v J     178 a.a. 178   Not given  
   more ...
There are no PDB entries containing tetracycline bound to this target protein, although there are 108 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 2:   UniProt id: P0AG59 (RS14_ECOLI)  -  30S ribosomal protein S14
UniProt id: P0AG59    100 a.a.  
1. 3j00 N     100 a.a. 100   Not given  
  2. 3j0u Q     100 a.a. 100   Not given  
  3. 3j0v Q     100 a.a. 100   Not given  
  4. 3j0x Q     100 a.a. 100   Not given  
  5. 3j0z Q     100 a.a. 100   Not given  
   more ...
There are no PDB entries containing tetracycline bound to this target protein, although there are 103 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 3:   UniProt id: P0A7V3 (RS3_ECOLI)  -  30S ribosomal protein S3
UniProt id: P0A7V3    232 a.a.  
1. 3j00 C     232 a.a. 232   Not given  
  2. 3j0u F     232 a.a. 232   Not given  
  3. 3j0v F     232 a.a. 232   Not given  
  4. 3j0x F     232 a.a. 232   Not given  
  5. 3j0z F     232 a.a. 232   Not given  
   more ...
There are no PDB entries containing tetracycline bound to this target protein, although there are 99 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 4:   UniProt id: P0A7W7 (RS8_ECOLI)  -  30S ribosomal protein S8
UniProt id: P0A7W7    129 a.a.  
1. 4tp8 H     129 a.a. 129   X-ray 2.80 Å
  2. 4tpa H     129 a.a. 129   X-ray 2.80 Å
  3. 4tpc H     129 a.a. 129   X-ray 2.80 Å
  4. 4tpe H     129 a.a. 129   X-ray 2.80 Å
  5. 4kiy H     129 a.a. 129   X-ray 2.90 Å
   more ...
There are no PDB entries containing tetracycline bound to this target protein, although there are 102 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 5:   UniProt id: P0A7U3 (RS19_ECOLI)  -  30S ribosomal protein S19
UniProt id: P0A7U3    91 a.a.  
1. 3j00 S     91 a.a. 91   Not given  
  2. 3j0u V     91 a.a. 91   Not given  
  3. 3j0v V     91 a.a. 91   Not given  
  4. 3j0x V     91 a.a. 91   Not given  
  5. 3j0z V     91 a.a. 91   Not given  
   more ...
There are no PDB entries containing tetracycline bound to this target protein, although there are 102 entries of the target protein (click the orange, plus icon for a list).
DrugBank drug Target 6:   Bacterial outer membrane
  No Pfam domain assignments available for this protein.
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 7:   UniProt id: P04156 (PRIO_HUMAN)  -  Major prion protein
UniProt id: P04156    252 a.a.  
1. 2lsb A     142 a.a. 142   NMR  
  2. 2kun A     148 a.a. 141   NMR  
  3. 2lej A     147 a.a. 141   NMR  
  4. 2lft A     142 a.a. 141   NMR  
  5. 2lv1 A     147 a.a. 141   NMR  
   more ...
There are no PDB entries containing tetracycline bound to this target protein, although there are 41 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

 

Other proteins with tetracycline bound in the PDB

There are 3 "non-target" proteins in the PDB containing the tetracycline molecule bound. That is, the UniProt code for the proteins is missing or does not match any of the drug targets listed above.

Protein 1:   UniProt id: P0ACT4 ()  -  Tetracycline repressor protein class D OS=Escherichia coli GN=tetR PE=1 SV=2
UniProt id: P0ACT4    217 a.a.  
1. 2vke A   200 a.a. 199   X-ray 1.62 Å
  2. 2trt A   198 a.a. 198   X-ray 2.50 Å
  3. 4b3a A   199 a.a. 197   X-ray 1.70 Å
The PDB contains 3 entries of tetracycline bound to this protein
Protein 2:   UniProt id: P0CE47 ()  -  Elongation factor Tu 1 OS=Escherichia coli (strain K12) GN=tufA PE=1 SV=1
UniProt id: P0CE47    393 a.a.  
1. 2hcj A   33 a.a. 33   X-ray 2.12 Å
  2. 2hdn A,C,E,G,...   33 a.a. 33   X-ray 2.80 Å
The PDB contains 2 entries of tetracycline bound to this protein
Protein 3:   UniProt id: P39075 ()  -  Multidrug-efflux transporter 1 regulator OS=Bacillus subtilis (strain 168) GN=bmrR PE=1 SV=3
UniProt id: P39075    277 a.a.  
3q5p A   276 a.a. 274   X-ray 2.94 Å
The PDB contains 1 entry of tetracycline bound to this protein

Key:    PfamA domain  Secondary structure  Bound drug molecule

The black crosses on the secondary structure diagrams indicate where the PDB and UniProt sequences differ.

Where there is more than one PDB model for a given UniProt sequence, the models are ordered by: 1. decreasing order of similarity to the UniProt sequence, 2. X-ray structures (in order of increasing resolution), NMR structures, and theoretical models. Clicking on any PDB code take you to the corresponding PDBsum page.

 

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