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DB00749 : etodolac

Approved drug etodolac ... 3 targets DB00749

Generic name: etodolac
 
Brand name(s): etodolac [usan:ban:inn], etodolacetodolic acid, etodolaco [inn-spanish], etodolacum [inn-latin], etodolic acid, lodine, lodine xl, ultradol.
Formula: C17H21No3
IUPAC Formula: 2-{1,8-Diethyl-1h,3h,4h,9h-Pyrano[3,4-B]indol-1-Yl}acetic acid

3
There are 3 target proteins defined in DrugBank for this drug.
 2 
2 of these target proteins have one or more structures in the PDB.
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Target proteins

DrugBank drug Target 1:   UniProt id: P35354 (PGH2_HUMAN)  -  Prostaglandin G/H synthase 2
UniProt id: P35354    603 a.a.  
1v0x A     604 a.a. 603   Theor. model
There are no PDB entries containing etodolac bound to this target protein, although there is 1 entry of the target protein in the PDB (see above).
DrugBank drug Target 2:   UniProt id: P23219 (PGH1_HUMAN)  -  Prostaglandin G/H synthase 1
UniProt id: P23219    599 a.a.  
 
There are no structures of the target protein in the PDB (click icon on left for list of closest matches)
DrugBank drug Target 3:   UniProt id: P19793 (RXRA_HUMAN)  -  Retinoic acid receptor RXR-alpha
UniProt id: P19793    461 a.a.  
1. 4nqa A,H     317 a.a. 317   X-ray 3.10 Å
  2. 3dzy A     302 a.a. 302   X-ray 3.10 Å
  3. 3e00 A     289 a.a. 289   X-ray 3.10 Å
  4. 3dzu A     289 a.a. 289   X-ray 3.20 Å
  5. 1lbd A     238 a.a. 238   X-ray 2.70 Å
   more ...
There are no PDB entries containing etodolac bound to this target protein, although there are 56 entries of the target protein (click the orange, plus icon for a list).

Key:    PfamA domain  PfamB domain  Secondary structure  Bound drug molecule

 

 

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